Cerebral Infarction On Serum Sicam-1 Content

Objective This study is to characterize the pattern of release of soluble intercellular adhesion molecule-1(SICAM-1). Methods In patients with acute cerebral infarction, the level of serum SICAM-1was measured serially two-layer antibody sandwich enzyme-linked immunosorbent assay (ELISA) in 100 patients with acute cerebral infarction and 30 normal controls. Results The level of serum SICAM-1 in patients with cerebral infarction 7 days after the onset was higher than that in normal controls (p<0.01). The level of serum SICAM-1 was significantly higher in the patients with large cerebral infarction than that in patients with medium or small cerebral infarction. (p<0.01) The same conclusion was found in the patients with cerebral infarction who have diabetes or infection at the same time. The level of serum SICAM-1 in patients with cerebral infarction increased within 7 days, decreased from 7days to 14 days, and got to the normal level after 3 weeks. Conclusions the level of serum SICAM-1 is closely related to the development of acute cerebral infarction .It is essential to have further study on the change of serum SICAM-1 in cerebral infarction.