Elderly Patients With Acute Coronary Syndrome Patients To Strengthen The Observation Of The Efficacy And Safety Of Lipid-lowering Therapy

Purpose:To evaluate whether intensive lipid-lowering is safe and efficient in old patients with acute coronary syndrome after percutaneous coronary interention.Methods:The study was a randomized,open trial。We enrolled 124 patients with definite diagnosis of acute coronary syndrome after percutaneous coronary interention .All patients were randomized to two groups initiated with 80mg(n=30) and 20mg(n=28)atorvastatin for three months.The fasting serum levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C),creatine kinase(CK),hepatic function ,renal function of the patients were measured before treatment and at 1 month,3months respectively.During the following-up,all adverse events and cardiovascular events were recorded.Results:After six-manth treatment,the levels of TC,TG and LDL-C were reduced significantly by18.63%,21.77%,17.33% in the 20mg atorvastatin group compared with baseline;whereas respectively reduced by 26.54%,37.36%,44.1% in the 80mg atorvastatin group as compared with baseline.As for HDL-C,it was increase of 5.13% in 20mg atorvastatin group and 3.48% in 80mg atorvastatin group.There were no statistical differences in adverse effects including abnormal liver enzyme between the two groups.Conclusion:The results suggest that intensive lipid lowering treatment with 80mg/d atorvastatin for old acute coronary syndrome patients was more powerful in decreasing levels of TG,TC and LDL-C,however,safety was similar in two groups.