The Cfmp Adjuvant Chemotherapy Ral Kps Score In Patients With Symptoms Of Clinical Observation,

Acute leukemia (AL) is a malignant clonal hematopoietic stem cell disease. The liver, spleen, lymph nodes and other organs are proliferated and extensive infiltrated by the abnormal progenitor cells and immature cells (leukemia cells) of the marrow inhibition of normal hematopoiesis. In the past 20 years, with the development of science and technology and the increasing means of chemotherapy, acute leukemia (AL) close and long-term efficiency significantly improve than in the past, whether it is completely remission (CR) or disease free survival. But there are still 10%-20%of the AL after chemotherapy can not reach the classic CR, which becomes intractable. This part of the case is called refractory acute leukemia (Refractory acute leukemia, RAL). The character of RAL is a poor response to chemotherapy, induction of remission rate, short survival; therefore, it is the problem of the treatment of leukemia.Abover all, the change from the clinical remission rate of acute leukemia to the treatment of refractory acute leukemia patients'quality of life research. The project uses the "Fritillary Thunbergii Bulb Complex Granules (FTBCG)" neoadjuvant chemotherapy in patients with refractory acute leukemia, KPS score and symptoms of clinical observation as the main purposes.PurPoseThe main purpose of this subject is to observe and research the influence the symptoms and KPS score after using "Fritillary Thunbergii Bulb Complex Granules (FTBCG)" in order to solve the current problem benefit of Anti-cancer treatmen.Research Methods235 cases of patients of all subjects were collected from Dongzhimen Hospital, Xiyuan Hospital, First Affiliated Hospital of Tianjin Medical University, Lang fang Hospital and so on. These patients must meet the diagnostic of RAL.The subject adopts Randomized double-blind, placebo-controlled, multicenter clinical trial methods.We make the standard diagnosis and unified clinical research programs and observation table.The aim of our subject is to know the KPS score and symptoms after use FTBCG.A random medivcine number and Patients were enrolled, While using the standard chemotheraPy,at 3 days before chemotheraPy using FTBCG or simulated agents,1 bag each time,2 times a day.14 days of continuous administration, with a standard chemotheraPy regimen for the treatment cycle, assessment the efficacy after the treatment.ResultsAfter exposing blind, the cases into the efficacy of statistics:the treatment group (compound Zhejiang beta particle group) contain 118 patients and117 patients are in the control group (placebo group).①The distributions of age and gender and all other demography characters are insignificant and comparable.②The two groups of KPS,their own cases were statistically significant before and after treatment comparison, P<0.005; between the two groups, no statistical significance.③The only fever reduction in the baseline visit to view of the three between the two groups was statistically significant (P=0.043), beta particles indicates that compound Zhejiang adjuvant chemotherapy on fever symptoms have some improvement.