Schizophrenia Cognitive Impairment Characteristics And Interventions

Objective: This study aimed to select the appropriate cognitive impairment in schizophrenia research tool to further study the cognitive dysfunction in schizophrenia features. Based on this study, analyze the correlation between the cognitive function and psychotic symptoms. And with foreign countries'more mature, more widespread application of cognitive behavioral therapy, combine the characteristics and extent of cognitive dysfunction in patients with schizophrenia, then develop pertinence therapy of cognitive behavior to explore its significence of schizophrenia psychotic symptoms and cognitive injuries.Methods: In this study, 232 patients with schizophrenia and 192 normal controls for the study, Applied Neuropsychology tools, as RBANS, Stroop, WCST scales, and the ERP Evaluation Tools to research study ,then analyze the characteristics of cognitive dysfunction syndrome of schizophrenia; with the 232 cases of schizophrenia, using PANSS assess the psychotic symptoms in patients, explore the relationship between the cognitive impairment in schizophrenia and the psychiatric symptoms; in all the subjects of psychotic symptoms and neuropsychological assessment and neurophysiological evaluation, recruiting 60 patients participat in the study interventions, through signing the letter of consent, and assigned randomly in accordance with the order of recruitment, compare with 30 conventional treatment group, combined with treatment group of cognitive behavioral intervention, applied SPSS16.0 statistical software to doing correlation analysis, multiple stepwise regression analysis, t test, etc. to explore the effectiveness of cognitive behavioral intervention.Results: (1) The characteristics of cognitive impairment in schizophrenia: each dimension of RBANS, positive symptoms, negative symptoms and normal control group were significantly different(p<0.05); in addition to the factors in the Stroop color interference, positive symptoms group, negative symptoms and normal control group were significantly differen(tp<0.05); in the WCST various factors except WCST13, the positive symptoms group, negative symptoms and normal control group were significantly different (p<0.05); in addition to the factors in the ERP LAT (N1), AMP (N2), LAT (P2), AMP (P3a) and AMP (B) CNV, the positive symptoms group, negative symptoms and normal control groups were significantly different (p<0.05); demographic variables of gender, age, education level, marital status, occupation, family history and other factors affect cognitive impairment in patients with schizophrenia. (2) Cognitive dysfunction of schizophrenia and psychotic symptoms have correlative relationship: in RBANS scale, each factor associated with positive symptoms, negative symptoms of psychotic symptoms have significantly negative correlation; positive and negative psychotic symptoms were significant predictors to RBANS. RBANS's total score and each dimension with psychiatric symptoms have direct prediction. (3) The results of cognitive behavioral interventions: Comparing the differences before and after intervention, the combined treatment group in the factors of psychotic symptoms was significantly greater than the conventional therapy group. In RBANS test, in addition to language function and attention, the combined treatment group decrease significantly larger than the conventional therapy group. In Stroop test, in addition to monochrome time, two-word interference time and the meaning of words, the combined treatment group decrease significantly larger than the conventional therapy group. ERP indexes in combined treatment group with LAT (N1), AMP (N2), LAT (N2), LAT (P2), LAT (P3a) and LAT (P3b) was significantly greater than the increase rate of conventional therapy group.Conclusions: (1) Schizophrenic patients have different degrees of cognitive impairment, particularly in attention, verbal memory and executive function, cognitive dysfunction in patients with schizophrenia may be affected by gender, age, educational level and family history and other factors. (2) Cognitive dysfunction of schizophrenia and negative symptoms, positive symptoms have significant negative correlation. Positive symptoms and negative symptoms of schizophrenia can predict the severity of cognitive impairment, these together affect the schizophrenia disease process. (3) On the basis of cognitive behavior therapy do the conventional therapy, not only improve the patients'psychotic symptoms, improve patients'neuropsychological and neurophysiological functions, but also show a good effect in correcting the patients'cognitive impairment.