Rhizome Part Of The Single-sided Needle Phenylpropanoids Class Of Chemical Composition

Zanthoxylum Dissitum Hemsl. are herbaceous genus of the family Rutaceae,which can promote blood circulation,dissipating blood stasis,detumescence and relieve pain,always used in the treatment of toothache,lumbago,women's menstrual overmuch,postpartum menstrual disorders etc.There are distributed in southwest of china,guangdong, guangxi,hunan,hubei,shangxi province,In hunanm,it is mainly distributed in the west.Owing to the fact that there are hundreds of complex active components in heral medicines.lt is imposible to identify all these substances and carry on quantitative analysis.Therefore,in order to obtain the chemical constituents from Zanthoxylum Disstum Hemsl.The EtOAc extract of Zanthoxylum Disstum Hemsl.was studied.ten compounds were isolated and purified by various chromatographic methods,such an silica gel column chromatography,macroporous resin column chromatography, sepades-LH-20column.and preparative thin layer chromatography(PTLC) and so on.According to the physiochemical properties and th comparision with literature data,the structure of five compounds were identified.There were elucidated as following:episesamin (comp.M), (+)fargesin (comp.I), (-)pluviatilol-γ,γ-dimethyallylether(comp.K),(-)eudesmin(comp.D), vanillin(comp.D),All of them are isolated from the genus for the first time. Otherwise,To establish a method for determining the content of espisesamin,fargedin, (-)pluviatilol-γ,γ-dimethyallyl ether in different growing years and different parts of zanthoxylum Disstum Hemsl by HPLC.the method can be used for quality control of zanthoxylum Disstum Hemsl and the contents of this three components of the stems of many years growning plants is more than other parts do.