| Objective: Coronary heart disease (CHD) is a complex multifactor and polygenic disorder that is thought to result from an interaction between an individual's genetic makeup and various environmental factors. The purpose of this study was to investigate the association between the polymorphism of CYP2C19 gene and Uigur patients with CHD in Xinjiang. Methods: There are 309 CHD patients and 310 control subjects, who were tested the genotype for the CYP2C19 SNP (rs4986893) with the methods of polymerase chain reaction and analyzed by restriction fragment length polymorphism. The risk factors were also included. Results: The genotype distributions of the control group and CHD group were in the Hardy-Weinberg equilibrium (P> 0. 05) . The CYP2C19 A allele was significantly more prevalent in CHD patients (6. 8% versus 1. 6%; P< 0. 001) . The frequencies of AA?AG?GG were 0. 6%, 12. 3% and 87. 1% in CHD group while ones were 0, 3. 2% and 96. 8% in controls. There was significant difference in frequencies of these three genotypes (P<0. 001) ; smokers in case were more than in control. The interaction of smoking and CYP2C19 polymorphism was the main risk factor of CHD in Uigur people, after adjusted the traditional risk factors such as sex, age, hypertension, diabetes mellitus, and hypercholesterolemia by Logistic analysis. The smokers of non-GG genotype were 6. 05-fold risk of CHD compared to the carriers of GG genotype without smoking. Conclusions: In Uigur smokers with the genetic polymorphism of rs4986893 of CYP2C19 may increase the risk of coronary artery disease. |
PDF Full Text Request