Chemokines Ccl21 And Interleukin-8 In Coronary Heart Disease

Background:Many studies have provided hat atherosclerosis (AS) is an inflammation within aterial wall. Inflammatory reaction plays an important role in the appearance and development of the atherosclerotic lesion. The inflammatory process of coronary arterial atherosclerosis results in atherosclerotic plaque formation and rupture, thrombus formation. The pathology basis of acute coronary syndromes (ACS) is the rupture or erosion of vulnerable plaque. Platelet accumulation and thrombus can cause complete or incomplete occlusion in coronary artery. Recent studies show that the stability of atherosclerotic plaque in coronary artery is responsible for ACS, the vulnerable plaque and subsequent thrombus formation result in ACS. In recent years, the role of chemokines in the pathogenesis of AS and ACS become a research focus. CCL21 and interleukin-8 belong to different chemokine family. Foreign studies reported CCL21 involved in the pathogenesis of AS and was related to plaque destabilization. The role of CCL21 and the relationship between CCL21 and IL-8 in the pathogenesis of AS and ACS have not been reported in our country.Aim:In order to investigate the role of CCL21 and the relationship between CCL21 and IL-8 in the pathogenesis of AS and ACS, the levels of chemokines CCL21 and IL-8 in serum of normal persons and patients with coronary heart disease (CHD) patients were measured, so as to search the foctors which are sensitive to evaluate the vulnerable plaque and provide proof for early intervention of ACS. Methods:Sixty-eight patients with CHD were divided into two groups: stable angina pectoris group (SAP) and ACS group. Twenty persons with normal results of coronary angiography were included as control group. Serum CCL21 level and IL-8 level were measured by enzyme-linked immunosorbent assay (ELISA), the severity of coronary artery was evaluated by Gensini scoring system.Results:Serum CCL21 level in the ACS group was significantly higher than that in the SAP group and the Iatter's was significantly higher than that in the control group, (180.1±42.6) ng/L vs (145.3±33.7)ng/L vs (105.8±33.9) ng/L (all P <0.05). Serum IL-8 level in the ACS group was significantly higher than that in the SAP group, (81.67±19.94)ng/L vs (69.80±21.16)ng/L(P <0.05), serum IL-8 level in the ACS group was significantly higher than that in the control group, (81.67±19.94)ng/L vs (56.65±13.31)ng/L(P<0.01), serum IL-8 level in the SAP group was significantly higher than that in the control group, (69.80±21.16)ng/L vs (56.65±13.31) ng/L(P<0.05). In CHD group: serum CCL21 level was positive corralated with LDL-C and negative corralated with HDL-C; CCL21 and IL-8 were not corralated with Gensini score. No corration was found between CCL21 and IL-8.Conclution:1 CCL21 level was significantly higher in the CHD group, in the ACS group was the highest. In the CHD group, CCL21 level was positive corralated with LDL-C and negative corralated with HDL-C, reflecting CCL21 plays a role in the appearance and development of AS and ACS , and may be related to plaque destabilization.2 IL-8 level was significantly higher in the CHD group, in the ACS group was the highest, reflecting IL-8 may be an inflammatory factor in the appearance and development of AS and ACS , and may be related to plaque destabilization.3 CCL21 and IL-8 were not corralated with Gensini score in the CHD group, reflecting that it is the vulnerable plaque not the the severity of coronary artery which determines the severity of coronary heart disease.