Clinical Study On Effects Of Potassium-magnesium Aspartate On Serum Nse And Mbp Of Patients With Diffuse Axonal Injury

Objective To observe the effects of potassium-magnesium aspartate (PMA) on the serum of neuron specific enolase (NSE) and myelin basic protein (MBP) with the diffuse axonal injury (DAI) and explore the protective effects of PMA in DAI.Methods Forty-six patients with diffuse axonal injury were randomly divided into two groups. The treated group was treated with potassium-magnesium aspartate plus conventional treatments, including oxygen, reducing intracranial pressure, organ functional support, nerve nutrition, prevention of complication etc. The conventional group was treated with conventional treatments alone. The concentrations of NSE and MBP in plasma were determined at admission and at 3, 7 and 14 days after treatment; Glasgow coma score (GCS) at admission and at 1 week and 2 weeks after hospitalization , the Glasgow outcome scale (GOS) after 3 months and awakening time were recorded to observe the long-term efficacy. Meanwhile, 20 healthy people, 12 males and 8 females aged 25-51 years old, were selected as control group.Results 1. The concentrations of the serum NSE and MBP in the patients with diffuse axonal injury were significantly higher than those in the healthful adults (P<0.05). These results show that DAI can elevate the concentrations of the serum NSE and MBP significantly.2. The concentrations of serum NSE and MBP in the treated group were significantly lower than those in the conventional group after the treated 7 and 14 days (P<0.05). These results indicate that Potassium-magnesium aspartate can reduce serum NSE and MBP levels of the patients with diffuse axonal injury.3. Before treatment, the GCSs of patients in the two groups had not statistical difference (P>0.05). The GCSs at 1 week and 2 weeks and GOS at 3 months of PMA group were significantly higher than those in the Conventional group (P<0.05). The treated group's awakening time was shorter significantly than that of the conventional group. These results show that Potassium-magnesium aspartate can improve the state of consciousness of patients with diffuse axonal and long-term prognosis.Conclusions 1. The levels of the serum NSE and MBP in the patients with DAI are significantly elevated. Detecting the concentrations of the serum NSE and MBP in the patients with DAI by enzyme-linked immunosorbent assay can help to assess the extent of axonal injury at different time.2. The treatment of the conventional therapy plus with PMA can reduce serum NSE and MBP levels of the patients with diffuse axonal injury, and can significantly shorten the awakening time, improve the patient's state of consciousness and long-term prognosis.