Detection To Eosinophil Major Basic Protein In Asthma And Clinical Study

BackgroundsAsthma is a chronic inflammatory condition of the airways that is characterized by a prominent eosinophilic inflammatory infiltrate. The eosinophil expresses its effector function by degranulation of toxic granule proteins. Eosinophils contain several cationic proteins, including major basic protein (MBP), eosinophil-derived neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPO). Among of the proteins, MBP is a known toxin, and application of physiological amounts of MBP to tumor cells, parasites, and bacteria causes direct toxicity. Effects of the protein is the most important causes of M2 receptor dysfunction and enhanced vagally mediated bronchoconstriction in asthma. Moreover, it can damage respiratory epithelium in asthma patients and stimulate the release of histamine and IL-5, IL-8 etc. It is suggested that major basic protein is the key substance in the development of asthma. ObjectiveThe tradition diagnosis methods, such as pulmonary function, blood routine, blood sedimentation rate, can not reflect exactly the inflammatory condition of the airways in asthma. So people always look for an accurate technique to replace the...