To Study Relation Of Msct Eevaluation Of Eepicardial Fat Volume To Coronary Artery Disease

Objectives (1)To study the relationship between the evaluated epicardial fat volume (EFV) by MSCT and coronary artery disease(CAD) in suspected anginal cases. (2)To explore the relationship between EFV and the severity of CAD and coronary risk factor in CAD patients. (3)To analyze the relationship EFV and body fat distribution in CAD patients. Methods (1)60 coronary artery of suspected anginal cases were evaluated by multislice computed tomographic coronary angiography and judged whether coronary artery become narrow and measured EFV. To analyze the relationship EFV and CAD.(2) In 35 CAD patients be diagnosed by coronary artery angiography(CAG), the heart and abdominal MSCT scan was acquired to measure epicardial fat volume (EFV), abdominal visceral fat volume(VFV), total fat volume(TFV) and subcutaneous fat volume(SFV); body length and body weight were measured, and to compute body mass index (BMI), Waist circumference(WC) and hip circumference(HC) were measured, and to compute waist to hip ratio (WHR);the severity of CAD was assessed by evaluating the extension of coronary plaques and the percentage coronary diameter stenosis. To analyze the relationship between body fat distribution and the severity of CAD,EFV and other indexes.(3) To collect Laboratory Measurements of 95 subjects and to analyze the relationship between EFV and them. Results (1)In 60 suspected anginal cases, EFV was significantly increased in obstructive coronary atherosclerosis (luminal narrowing >or=50%) group compared with no coronary atherosclerosis group(P<0.01). Logistic regression analysis for the relationship between obstructive coronary atherosclerosis and clinical parameters, EFV enter the regression equation, and a positive correlation was shown between EFV and coronary artery narrowing(P<0.01,OR=1.025>1). EFV is a risk factor of coronary artery disease. In the 95 subjects, a positive correlation was shown between EFV and age , fasting plasma glucose, TG; a negative correlation was shown between EFV and HDL-C(P<0.05).(3) In 35 CAD patients be diagnosed by CAG, a positive correlation was shown between the severity of CAD and WC, abdominal VFV and TFV, EFV(P<0.05 or P<0.01), and the relationship between the severity of CAD and EFV is the closest(r=0.498); The severity of CAD and weight ,BMI,WC,WHR, abdominal SFV are not significantly relative(P>0.05). (4)A positive correlation was shown between EFV and BMI,HC,WC,WHR, abdominal TFV and VFV(P<0.05 or P<0.01), and the relationship between EFV and abdominal VFV is the closest(r=0.637); EFV and weight, abdominal SFV are not significantly relative(P>0.05). Conclusion In suspected anginal cases, EFV was significantly related to obstructive coronary atherosclerosis, EFV is an independent risk factor of CAD . In CAD patients be diagnosed by digital subtraction arteriography coronary angiography, a positive correlation was shown between EFV and evaluating the extension of coronary plaques, the percentage coronary diameter stenosis. Measurement of EFV may provide another useful noninvasive indicator of heightened risk of CAD . EFV may act as an evaluating indicator of visceral obesity. To compere with whole and peripheral obesity, abdominal obesity is an more important influencing factor. Visceral fat , especially EFV is closely related to CAD. Evaluated EFV by MSCT is accurate and reliable and repeated.We may three-dimensional evaluate EFV by MSCT. This method have widely prospect in evaluating EFV.