Correlation Between Epicardial Fat Volume And Coronary Heart Disease By 320-Row Low Dose CT

Background: Coronary heart disease(CHD)is a disease caused by many risk factors.According to the World Health Organization,cardiovascular disease is the leading cause of all deaths.Early intervention for reversible risk factors of coronary heart disease can effectively reduce its morbidity and mortality;Therefore,it is very important to find out the risk factors of coronary heart disease and related examinations,and to carry out early prevention and intervention treatment.Epicardial adipose tissue(EAT)has been recognized as a new reversible risk factor for coronary heart disease in recent years,it can secrete many inflammatory mediators and adipokines,thereby promoting the development of coronary atherosclerosis.However,it is still in the research stage and there are some disputes.Objective: To investigate the relationship between the volume of Epicardial adipose tissue(EAT)and coronary heart disease and the severity of coronary artery disease by 320 row low dose CT.Analyed the predictive value of EAT for coronary heart disease.Methods: 120 cases of suspected coronary heart disease were collected retrospectively,Computed tomography angiography(CTA)with Toshiba 320-row CT and coronary angiography(CAG)were performed at the corresponding period.77 patients were identified as coronary heart disease group with coronary angiography,43 patients with normal or narrow <50 degree of coronary artery angiography as control group.All patients using Toshiba 320-row CT post-processing workstation measured epicardial adipose tissue volume.According to the results of coronary angiography,Gensini score for assessment of severity of coronary artery disease.Collect the general clinical data of all included samples.Statistical analysis using SPSS17.0: To screen the high risk factors of coronary heart disease by comparing the general clinical data and the average EAT volume of the coronary heart disease group with the control group.Evaluation of the relationship between EAT volume and coronary heart disease by binary logistic regression analysis.Spearman correlation analysis and independent sample t test were used to investigate the correlation between EAT volume and severity of coronary artery disease in the coronary heart disease group.The ROC curve of the relationship between EAT and coronary heart disease was drawn,Evaluation of predictive value of EAT for coronary heart disease.Results: There was a significant difference in age,uric acid,hypertension,diabetes,smoking and EAT between two groups(P<0.05).Logistic regression analysis showed that EAT was an independent risk factor for coronary heart disease.Spearman analysis showed that Gensini score and the number of lesions were both positively correlation with EAT volume in coronary heart disease group.(r=0.356,r=0.412;P=0.001,P<0.001).After stratification of the number of lesions,the Gensini score and EAT were analyzed by t-test in different lesions.Statistical analysis showed no significant difference between single lesion and the double lesion group in EAT(P> 0.05),and significant differences in the other groups(P<0.05).EAT volume 156.89 mL was the best cut-off point for predicting coronary heart disease,at which time the Youden index was the largest(0.424);The prediction of coronary heart disease sensitivity and specificity were 49.4% and 93.0% respectively,The area under the curve is 0.727,95% CI: 0.638-0.816;there was statistical significance(P<0.000).Conclusion: EAT was the independent risk factor of the coronary heart disease.There was a positive correlation between the severity of coronary atherosclerosis and the number of lesion branches.EAT volume has a good predictive value for coronary heart disease.