Association Of Epicardial Fat Volume With Coronary Artery Calcification In Chronic Kidney Disease Patients

Objective To evaluate whether epicardial fat volume(EFV)is related to coronary artery calcification in chronic kidney disease patients.Methods 30 healthy people of physical examination center as the control group and 120 patients with chronic kidney disease were undergone heart scanning by multi-slice computed tomography.Cross—sectional tomographic cardiac slices from base to apex were traced semiautomatically using a Volume Viewer of AW4.3 off—line workstation,and EFV Was measured by assigning Hounsfield units ransins from -30 to -250 to fat.The coronary artery calcification score was assessed by Ca Scoring software.While collecting blood test and the body mass index(BMI),dialysis way,history of diabetes and coronary artery disease were used to analyze the relationship between epicardial fat volume and other risk factors in patients with chronic kidney disease.Results(1)60.8% male(Mean age 62.8years),39.2% famale(Mean age66.6years),73.3% had coronary artery disease,55.8% had diabetes,21 patients of peritoneal dialysis and 9 of hemodialysis.(2)EFV was apparently higher in stage 4–5D CKD group compared with the control group[(140.03±54.71),(145.01±64.56)and(141.45±62.04)cm3 by(92.42±39.56)cm3,P=0.007,0.015 and 0.001);EFV Was significantly increased in coronary artery disease group compared with no coronary artery disease group(140.67±70.31cm3,105.22±61.49cm3,P=0.002).EFV was obviously higher in diabetes group than no diabetes group(148.41±65.78cm3,110.53±62.37cm3,P=0.007).CACS was apparently increased in stage 3–5 CKD group compared with the control group[140(574.5),4.3(47.1)P<0.001].(3)When the patients were divided into four groups acconding to the e GFR,EFV was associated with CACS(rs=0.539,P=0.004)in the general population,and the association remains more robust in patients with CKD5(rs=0.841,P<0.0001).EFV is related to age(r=0.662,P=0.005),BMI(r=0.648,P=0.009)and HDL-C(r=-0.433,P=0.024),rather than the way of dialysis.CACS was related to age(P<0.05),BMI(P<0.05)and e GFR(P<0.05),not HDL-C and LDL-C.Conclusion Measurement of EFV may provide another useful noninvasive indicator of coronary artery calcification in CKD patients.