Intervention Action Xue Bi Jing Parenteral Solution To Tnl-α,il-10 In Blood Serum Of Aopp Patients

Objective:1.Investigation about expression level of pro-inflammation factor TNF-a and anti-inflammation factor in AOPP patient's blood serum.2. To explore intervention action about Xue Bi Jing injection to inflammation factor in AOPP patient's blood serum.Methods:1.case grouping:40 patients with severe AOPP were randomly divided into 2 groups: routine treatment group(20 example):to provide specially antidote.Xue Bi Jing treatment group(20 example):in background of routine treatment adding Xue Bi Jing, health examination persons were blank control group((20 example).2.Collection and disposal about blood sample:Leave behind 3ml whole blood after leaving to -70℃icebox in the first,third,fifth,seventh day.3. Applying ELISA reagent box to mensurate expression level of TNF-a,IL-10 in blood serum in patients with AOPP.4. Curative effect:Reach to atropine time, variety of Acetylcholine esterase, whether or not appear bounce phenomenon and middle syndrome, number of days be in hospital, prognosis.5.Adopt SPSS16.0 software bag to statistics analysis about date disposal.Results:1. TNF-a,IL-10 variety in blood serum:treatment groups were no significantly difference (t=-0.360,P>0.05; t=-0.078,P>0.05), more significantly than blank control group(P <0.01) in the first day in hospital. After 3 days of treatment, TNF-a,IL-10 in blood serum in patients with AOPP were decreased than before treatment, but Xue Bi Jing treatment group were decreased more significantly than those of routine treatment group (the third day t=2.260,P <0.05, t=2.478,P<0.05; the fifth day t=2.478,P<0.05, t=-2.496,P<0.05; the seventh day t=-2.155,P <0.05, t=-3.087,P<0.01).2. Curative effect observation:AChE variety in blood serum: treatment groups were no significantly difference (t=1.158, P>0.05), more significantly than blank control group(P<0.01) in the first day in hospital. After 3 days of treatment, AChE in blood serum in patients with AOPP were decreased than before treatment, but Xue Bi Jing treatment group were decreased more significantly than those of routine treatment group (the third day t=2.895,P<0.01,the fifth day t=2.569,P<0.01, the seventh day t=2.736,P<0.01). Reach to atropine time and number of days be in hospital and happen of combine symptom Xue Bi Jing treatment group were shortened more significantly than those of routine treatment group (t= 2.240, P<0.05,t=2.687, P<0.05, P<0.05). Prognosis Xue Bi Jing treatment group were better significantly than those of routine treatment group (P<0.05)Conclusion:1.Exist inflammation responses in course of diseases.2.Xue Bi Jing can apparently reduce level of TNF-a,IL-10 in blood serum in patients with AOPP, shorten number of days be in hospital,reduce happen of combine symptom and then improve Prognosis, reduce mortality.