Reserch About Feilaokang's Role Of Experimental Tuberculosis Mice's Immune Regulation

Objective To study the effect of FeiLao-kang (FLK) on the changes of immunological indices of mouse tuberculosis model and provide the research evidence of FLK for the treatment of tuberculosis.Methods After the animal model establishment, the mice were randomly divided into the following groups:high-dose group of FLK, moderate-dose group of FLK, group of RFP, group of INH, group of FLK add RFP, group of FLK add INH and a control group. The RFP capsules, FLK, NS were given separately for 28 days. To observe the changes of thymus index, T-lymphocyte subsets, IFN-y, IgG in experiment mouse.Result①The high-dose group of FLK to a marked increase in thymus index of mice (P<0.05);②The number of CD4+ T cells increased significantly in high dose group of FLK (P<0.01, P<0.05); the number of CD8+ in each group Comparison between the difference was not significant (P> 0.05); The ratio of CD4+ /CD8+ were significantly in lower model group, the difference was significant (P<0.01), The ratio of CD4+ /CD8+ significantly reduce the decreased in high-dose group of FLK,the difference was significant (P<0.01);③the serum levels of IFN-y and IgG under the groups treated with high-dose FLK was increased (P<0.05).④To compare with the latter line antituberculosis drug group:to observe by the result of pathological histology, liver multiple thanatosis had lessened in FeiLao-kang group and the latter line antituberculosis drug group.Conclusion①FLK show definite immuno regulatory and anti-tuberculosis effects.②In the animal experiment, we can get good therapeutic efficacy from using FeiLao-kang group to treat TB.③FeiLao-kang had the certain protecting effect on liver pathologic lesion induced by antiphtisy and chemotherapy.