Two Sharp Anti-tumor Monomer Composition Rda Dropping Pills Pharmaceutical Research

Raddeanin A (RDA) is an anti-cancer monomer compound that extracted and purrified from"Liangtoujian"—Anemone raddeana Regel, but it is difficult to be dissolved in water. This experiment chooses water-soluble matrix to make it into water-soluble dropping pill.This mathod not only increase its solubility in the body, but also improve its bioavailability , which is of higher academic value and clinical application value. This topic separated a RDA monomer from Anemone raddeana Regel first and used HPLC to determine its purity is above 90% .Meet the national standard for one types of new traditional chinese medicine .Then carry on an investigation into the molding technique of dropping pills:determined the matrix and the refrigerant of the dropping pill first, then with medicine and matrix mixed ratio, matrix and matrix mixed ratio , the medicine liquid temperature as affecting factors, each factor chooses three levels and carries on L9(34) experiments ,use" appearance score " and objective indicators "dissolve and spread time" to carry on comprehensive score , Determined the best condition for molding technique of dropping pills.Finally carried on a research to the drip system technology:According to the the best condition which have determined for modeling technology, with ring dripper outside diameter size and inside diameter size, drop speed, drop distance and refrigerant temperature for investigate factor, each factor chooses three levels and carries on L9(34) to experiment, with pills of weight variation coefficient of variation for investigate indexes, determined the best drop system craft of dropping pills.According to the best the craft modeling craft and the best drop system made three batches of dropping pills.And carried on a research to the quality standard of dropping pills. TLC was carried out on the pills in the identification of RDA ,used HPLC to determine its content . The results show that the method accurate and credibility, can be used as the assay method of RDA dropping pills. This study also investigated the stability of drugs, in the situlation under the premise of commercial packaging, carry on 0 months, 1 month, 2 months, 3 months and 6 months of stability investigation to the RDA dropping pills. Separately from the external appearance, distinguish, determination, bulk melting time and microbial limit to inspect. The results show that, in the study periodis, RDA dropping pills stable in quality. The above -mentioned research provide a scientific basis for the Anemone raddeana Regel saponins component RDA medicine research and development,and Laid a solid foundation.