| A fluid bone glue with high vwascosity, low freezing point and high water resistance was synthesized with traditional bone glue which was modified by micromolecule after been hydrolyze by alkaline. The effect of reaction temperature, alkali quantity, reaction time on the viscosity and freezing point of modified bone glue were investigated, and the optimal process conditions of preparing modified bone glue were obtained by single factor experiment method. The results showed that the best process conditions of modified bone glue were that the amount of alkali was 0.8 g, alkaline hydrolysis temperature was 60 ℃, alkaline hydrolysis time was 100 min and the amount of ethanol to 2 m L.when bone glue and water were 25 g and 30 m L, respectively.This modified bone glue had good thermal stability and some properties, such as freezing point at 0 ℃, viscosity at 1600 m Pa·s,shear strength at 5.88 MPa and working life at 90 d.This paper use Al3+、Zn2+、Cu2+ three kinds of metal ions on modified collagen, and various types of modified bone glue application performance testing, and its structure was characterized(FT-IR, SEM). The test results were compared with the original industry, the results showed that: the metal ion modified bone glue on the adhesive strength, water resistance, the probation period were better than glue industrial glue. The three kinds of modified collagen compared to each other and found, Al3+, and Zn2+-modified gelatin overall performance was better than Cu2+ modified gelatin; Al3+ modified glue shear strength was slightly better than Zn2+ modified gelatin, and Zn2+ modified gelatin water resistance was better than Al3+ modified gelatin.In the thesis, Al3+ modified bone glue adhesive material(CA) was prepared through adopting Al3+ to modify bone glue. Studied the modification mechanism of Al3+ on the bone glue, the modification mechanism was verified through adopting the FT-IR(Fourier transform infrared spectroscopy), XRD( X-Ray Diffraction), PL( Fluorescence spectra) and XPS( X-ray photoelectron spectroscopy), CA was conducted for water-proof representation through adopting SEM( Scanning electron microscope) and a surface wetting angle detector, and the testing result showed that Al3+ reacts with the NH and C O of the peptide chains of bone glue molecules to enable the peptide chains of the bone glue molecules to be cross-linked through Al3+ to form a stable net structure with five-membered rings; the CA membrane surface was more neat, smooth and dense than the bone glue membrane surface and the bone glue membrane; the surface wetting angle test indicated that the contact angle of CA was 92.45 DEG and the contact angle of the bone glue membrane was only 42.58 DEG.A type of liquid bone glue at room temperature modified by Al(III) ions was prepared by the application of aluminum sulfate. The bone glue materials modified or not prepared in this paper were characterized by means of TGA, DSC, SEM, FT-IR and the wetting angle detector. The optimum hot-pressing parameters in the process of plywood by using modified bone glue were discussed through the orthogonal experiments. The results show that aluminum sulfate has little impact on the stability of bone glue. Hot-pressing temperature has the greatest influence on the bond strength of the modified bone glue. At the hot-pressing temperature of 110 ℃, the hot pressing time of 30 min(at the state of wet glue: 10/20 min), the hot-pressing pressure of 3 MPa(at the state of wet glue: 4 MPa), and the storage time of 48 h, the plywood compressed by using this modified bone glue has the largest bond strength. Wetting Angle analysis of collagen membrane shows that water resistance of the modified bone glue was significantly enhanced. With an algae structure on the fracturesurface, very neat collagen membrane structures are found in the modified bone glue by SEM analysis. |
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