| Multisubstituted pyran pyrazoles and sprio indoline-3,4’-pyran[2,3-c]pyrazoleswidely exist in nature, of which the similar skeleton structure was founded in manydrugs and natural products with biological activities. Studies on bioactivities showedthat these compounds have good analgesia, antibacterial, antitumor, anti-inflammatory,deinsectization and other biological activities. So it is significant to find out a simple,efficient, good yield, characteristics of atomic economy method for the systhesis ofthese compouds. This paper will be divided into the following two parts.The first part is a review. Introduces the development status of multisubstitutedpyran pyrazoles and spiro indoline-3,4′-pyrano[2,3-c]pyrazoles, the research purpose,meaning, as well as the research content and plan of this topic.The second part is about experiment, it introuduced the major work.1. Cs2CO3-promoted one-pot synthesis of5-amino-7-aryl-7,8-dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrile derivatives5-Amino-7-aryl-7,8-dihydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carbonitrilediversities were synthesized by three-component one-pot reaction of3-amino-1,2,4-triazole, aryl aldehyde, and malononitrile in the presence of Cs2CO3(10mol%) as a catalyst.2. Pyrrolidine-catalyzed four-component one-pot synthesis ofdihydropyrano[2,3-c]pyrazole derivativesA series of dihydropyrano[2,3-c]pyrazole derivatives were synthesized viafour-component one-pot reaction of β-ketoester, hydrazine, ethyl glyoxalate or ethylpyruvate, and malononitrile in ethanol under refluxing condition catalyzed bypyrrolidine.3. Rapid and efficient one-pot synthesis of spiro indoline-3,4′-pyrano[2,3-c]Pyrazole derivatives catalyzed by L-proline under ultrasound irradiationThe spiro indoline-3,4′-pyrano[2,3-c]pyrazole derivatives will be synthesized at high yield under the condition of ultrasonication and normal atmospheric temperaturewith L-proline as catalyst in a short time. |
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