Research On Universal Representing Approach Of Myocardial Cell Electrophysiological Model And Its Visualization

In Virtual Heart, the new theories, methods and technologies of modern computer science field are applied to human cardiac physiology studies. Mathematical quantitative models on different levels including cell level, tissue level and organ level are built to describe the basic principles for all kinds of complex processes in physiology. Virtual Heart is a research area with highly interdisciplinary nature and broad prospects of applications. It makes the understanding of human cardiac physiological response mechanism by biological and medical researchers more systematic, coherent and standardized, and provides more intuitive and more efficient directions for the assessment of medicine efficacy and the research of clinical experiments.The establishment of myocardial cell electrophysiological models is the foundation of the whole research for Virtual Heart. The way those models are described directly impacts the performance of simulation system for hearts.Referring to the knowledge of myocardial cell electrophysiology, the dissertation mainly studies the universal representing approach for myocardial cell electrophysiological models. The research includes following parts:(1) Extract the abstract architecture of myocardial cell and achieve the division of contents. First, investigate all myocardial cell electrophysiological models, and extract those common concepts in models. Then confirm the dependences between elements, and construct the abstract architecture of models.(2) According to the requirements of myocardial cell electrophysiological modeling, design and implement a Myocardial Cell electrophysiology Modeling Language (MCML). As an XML-based language, MCML provides models with high reliability and compatibility, and improves the universality and portability of models. In MCML, semantic relevance and aspect dependency provide a guarantee for the integrity of models.(3) Design and implement a MCML editor. The objective of the MCML editor is to provide a graphical user interface that allows users to create MCML models through a visualized diagram view, and thus generate MCML XML scripts from the given model structures. Since mathematical equations will be involved in defining the model using the language MathML, an existing MathML editor is to be integrated into the MCML editor as a plug-in feature to manage mathematical equations related operations. It enables users to get rid of the tedious process of manually editing model documents, and promote the application for MCML in the description of myocardial cell electrophysiological models.(4) Using MCML editor, edit an instance of sinoatrial node model and an instance of myocardial ventricular model respectively. Representing test is carried out to evaluate above two models edited, and to give an objective evaluation for the expression performance of MCML and the system performance of MCML editor by analyzing the result.