Development Of Fluorescence Sensor For Sugar Comprise Boronic Acid

Saccharides are nature's conveyors of energy and therefore essential for cell survival. The breakdown of glucose transport has been correlated with certain diseases: renal glycosuria, cystic fibrosis, diabetes, and human cancer, seriously affected our normal life. One of the major challenges in the management of the diseases like diabetes is the monitoring of glucose concentrations. To develop a continuous monitoring system, it would be ideal to use an implantable device that is in constant contact with the biological fluid to give a continuous reading of glucose concentration. Chemical sensors do offer the advantage of higher stability and relatively easy manufacturing. Such a concept has already been put into test by companies such as sensors for medicine and Science. we are interested in the development of fluorescent sensor system for saccharides based on boronic acid– diol.Firstly , monoboronic acid compound comprise naphthalene was synthesized and prepared to be fluorescent sensors in 80% methanol/water buffered at PH 6.86. We tested the recognition between the sensory system and D-glucose, studied the influence of the electron transfer to sensory sensitivity. We also studied the selectivity to saccharides of two different sensory system.Secondly, the function between boronic and sugar was imported into vesicular system, a vesicular fluorescent sensor based on phenylboronic acid-glucose recognition in aqueous DBBTAB vesicles containing ARS was prepared. The vesicular sensor enhanced the sensitivity for glucose about 7-8 fold compared with the corresponding aqueous solution, which is ascribed in enhancing the local concentrations of glucose on the surface of covesicles. This enhance of local concentrations made the sensitivity of fluorescence sensors increased, and the absolute fluorescent intensity enhanced obviously. Based on these research, aggregation also can be employed as carrier for sensors to develop a new continuous glucose monitoring systems, and as an implantable device that is in constant contact with the biological fluid to give a continuous reading of glucose concentration.