Study On The Novel Supramolecular Chemosensors Based On Cyclodextrin And Porphyrin Derivatives

Supramolecular chemistry is interdisciplinary-cross subject, which has been of great importance for developments within coordination chemistry, organic synthesis, analytical chemistry, and bioorganic and bioinorganic chemistry. Supramolecular action is a kind of molecular interaction with molecular recognition ability. It includes Van der Waals and electrostatic interactions, hydrogen-bonding,π-bonding and hydrophobic interaction, which are accompanied by spacial effect.A variety of artificial receptor molecules, such as cyclodextrin (CD), crown ethers, calixarenes and porphyrin, as typical host compounds, have attracted enormous research interest in their molecular recognition. Among them, CDs having an interior hydrophobic cavity and an exterior hydrophilic environment, as a buildup element of second generation supramolecule, can accommodate many organic, inorganic and biological molecules in their toroidal cavity to form stable host-guest inclusion complexes. Therefore, they have been paid much attention by the researchers of supramolecular chemistry. Due to the special activity of porphyrins, research efforts in analytical chemistry have been focused on these compounds.More and more analytical chemists tried to combine the 5, 10, 15, 20-tetraphenylporphyrin (TPP) with other functional molecules to obtain the analytical reagents with high sensitivity. Recently there have been of great interests in chemosensors because of its higher sensitivity and large Stocks shift. It is interesting to synthesize some porphyrins and develop them as chemical sensing elements to detect some substances in micro-level.This thesis is mainly centered on the following researches:(1) An electrochemical sensor modified with multi-walled carbon nanotubes/β-cyclodextrin (MWNTs/β-CD) film was fabricated for the determination of rutin (Chapter 2). The electrochemical behavior of rutin at the chemically modified electrode was investigated by CV. The response mechanism of MWNTs/β-CD film for rutin was based on the inclusion interaction ofβ-CD for rutin.The MWNTs/β-CD film showed improved analytical performance characteristics in electrocatalytic oxidation and reduction for rutin compared with the MWNTs film and bare glassy carbon electrode (GCE). A linear calibration plot was obtained covering the range from 4.0×10-7 mol?L-1 to 1.0×10-3 mol?L-1 with a detection limit of 2.0×10-7 mol?L-1. This electrochemical sensor showed excellent sensitivity,...