Efficient Indole-based Receptor For Cu²⁺ Ion

Considerable research interest has been focused on the development of chemosensors in the field of life science, material seience and environmental science during the last 20 years. A number of chemosensors have been developed for selective recognition of different species on the basis of different host-guest chemcal interactions, such as hydrogen-bonding, electrostatic force, metal-ligand coordination, hydrophobic and van de Waals force interactions, etc. In the recently decades, many cation fluorescent chemosensor were reporped, most heavy metals irons can not be determined by spectrofluorometry, while a fluorescent complex formed in the reaction between heavy metal ions and organic reagents can be determined by Spectrofluorometry.In the thesis, we prepared two types of copper fluorescent sensor and one types of zinc fluorescent sensor, and research application on copper and zinc ions fluorescence analysis. The thesis was comprised of four parts.ChapterⅠserved as an overview of sreseareh progresses of fluorometry. Detailed review responsive of fluorescent Sensor and fluorescent Sensor on the basis of nanomaterial to different ion. In the end, the objectives of this study have been described.In the Chapter 2, a new fluorescent INDOLE was designed and synthesized through the condensation of indole-3-aldehyde and N-(2-hydroxyethyl) ethylenediamine. It exhibits good sensitivity and selectivity for the copper cation over other cations such as K+, Na+, Ca2+, Cr3+, Mg2+, Zn2+, Al3+and Fe3+. The fluorescence intensity of the sensor was decreased with increasing the concentration of Cu2+. The analysis of the Benesi-Hildebrand equation indicated the formation 1:1 complex of 1 and Cu2+with the association constant Kass=3.34×105 M.In the Chapter 3, a highly fluorescent material (MWNTs-INDOLE) is synthesized by carbon nanotube-based indole derivative, and characterized them with FTIR and TGA. The characterization data indicated that the organic ligand was successfully grafted on the surface of the arbon nanotube. This meterial shows excellent selective for the Cu2+ ion over other cations such as Zn2+, Cd2+, Mg2+, Ca2+ and Ni2+. Moreover, the fluorescence intensity quenched to 50% when addition of 1 equivalent of Cu2+In the Chapter 4, quinoline group modified multifunctional silica nanoparticles having high magnetization and excellent Zn2+ selectivity have been successfully prepared. These multifunctional nanoparticles were characterized by high resolution transmission electron microscopy, Fourier transform infrared spectroscopy, thermal gravimetric analysis, X-ray powder diffraction and vibrating sample magnetometer. The characterization data indicated that the organic ligand was successfully grafted on the surface of the magnetic silica nanoparticles. The fluorescent properties of the nanosensor were characterized and employed to detect Zn2+ with excellent selectivity and sensitivity (0.1μM) toward Zn2+ over other cations even in trace amount.