Clinical Study On Treatment Of Cardiac And Kidney

Objective:Through randomized controlled study of 90 cases from the community generalized anxiety disorder (GAD) patients, provide safety and effectiveness of treatment for GAD clinical evidence.We are committed to promote the application of traditional Chinese medicine in the treatment of GAD in the community, improving community health agencies focus on GAD achieve timely detection and effective treatment purposes.Methods:Choose GAD patients from the three community centers of the Third Affiliated Hospital of Beijing University of TCM and recruitment of the four community centers surrounding the hospital.90 cases of GAD patients who met the inclusion criteria were randomly divided into experimental and control groups,45 cases each.Experimental group to HLEJ Chinese medicine granules treatment, while control group received lorazepam.The treatment lasted two weeks. Post respectively before treatment, one week and two weeks of treatment Hamilton Anxiety Scale (HAMA), generalized anxiety syndromes assessment form (type of disharmony between heart and kidney), Social Disability Scale (SDSS), the amount of side effects table (TESS) evaluation, three months after the end of the trial follow-up. Results using HAMA reduction rate to assess the clinical syndromes index to evaluate the clinical efficacy; and before treatment and after 2 weeks of treatment general physical examination, liver and kidney function, urine will be routine and electrocardiogram to evaluate drug safety.Result:1. Clinical Observation indicators:There was significant statistically (P<0.01) difference between experimental group and control group of HAMA score and TCM symptom score in treatment 1,2 weeks after declined, the experimental group before and after treatment, the control group before and after treatment the difference is statistically significant (P<0.01). After 1 week of treatment,2 weeks after the experimental group and control group of HAMA scores compared both P>0.05, indicate no statistically significant difference between the test group and the control group and two treatment schemes in HAMA scores decreased without significant difference; In terms of TCM syndrome score, two groups after 1 week of treatment, TCM syndrome score comparison, P<0.05, the difference was statistically significant; treatment after 2 weeks of TCM syndrome score comparison, P<0.01, the difference is statistically significant, showed that the decrease of TCM syndrome score of the experimental group than control group, and with the increase of treatment time and the more obvious.2. Comparison of clinical efficacy:The experimental group and control group the anxiety level of improve the total effective rate of the treatment 1 week respectively after 54.76% and 52.38%, after 2 weeks were 78.57% and 71.43%,1 week of treatment between the two groups in the total efficiency compared with no significant difference (P>0.05), indicating that 1 week of treatment in the two therapeutic regimens in the treatment of clinical anxiety improve curative effect quite. There was no significant difference in the total effective rate between the two groups (P>0.05), indicating that there was no significant difference between the experimental group and the control group in the improvement of clinical anxiety level after 2 weeks of treatment. Syndrome of traditional Chinese medicine clinical curative effect:after 1 week in the experimental group and the control group, the total efficiency was 59.52% and 40.48%. After 2 weeks was 90.48% and 69.05%. By statistical analysis, groups of TCM syndrome clinical efficacy compared with 1 week difference has statistical significance (P<0.05). In the experimental group was better than the controls,2 weeks when the difference is more obvious (P<0.01), indicating that in the test group TCM syndrome clinical curative effect was significantly better than the control group.3. Safety and side effects observed:in the process of treatment, no serious adverse events. General examination of two groups of patients before and after treatment, liver and kidney function, blood in the urine routine and electrocardiogram examination had no obvious change. And observe the adverse event, the control group patients with anorexia in 3 cases,3 cases were mild lethargy, mild headache in 1 cases, slight sweat out of the 2 cases, more than after drug withdrawal symptoms can disappear; Patients have mild diarrhea observed in 3 patients, recovery without withdrawal and special treatment. Compare two groups of TESS score difference, was statistically significant (P<0.01), characterized by experimental side effect is less than the control group.4. Quality of life assessment:1,2 weeks after treatment in both groups of SDSS score compared with group before treatment, there were no statistically significant difference (P>0.05), showed that two kinds of treatment for short-term treatment of patients life quality improvement is not obvious.5. Follow-up results:After 3 months follow-up,61 cases were followed up,31 cases in the experimental group and 30 cases in the control group. There were 21 patients in the experimental group did not relapse,6 patients in 3 months after the withdrawal of the patient’s condition repeatedly.Questioning the medical history, all complaints have family chores, work pressure and other effects of emotions, consider the condition and the relevant. The rest of the patients lack of drug withdrawal for 3 months, no recurrence. The control group of 10 patients within 3 months without recurrence,13 cases of recurrent disease in patients with drug withdrawal within 1 months, once again need medication.Conclusion:1.This study results show that the onset of old people in the community of GAD rate is higher, old age is the peak age of onset of GAD, timely detection and early treatment is an important aspect of effective community prevention and treatment of GAD.2. Huanglian ejiao decoction treatment of disharmony between heart and kidney type of GAD is safe and effective.It can improve the clinical symptoms and syndromes of anxiety and have few side effects.Its short-term efficacy is equivalent of lorazepam, and good in the community use of Chinese medicine treatment and the promotion of practical value GAD significance. So it is worthy of popularization and application in the community.