| ObjectiveThe modern research summary about the drug therapy of psoriasis medicine ancient literature and Chinese and Western medicine treatment.To observe the clinical efficacy and safety of blood of psoriasis Lithospermum cream in the treatment of detoxification decoction combined with vulgaris dryness syndrome. Explore the application of traditional Chinese medicine preparation for the treatment of difficult skin diseases, to explore the formulation optimization of traditional Chinese medicine.Through the experiment research vulgaris psoriasis blood dryness syndrome in patients with lesions of skin barrier function damage, and the repairing effect of Lithospermum cream for external use on the skin barrier function in patients with.MethodTo collect, select, summarize and organize the records of the existing traditional Chinese medicine ancient books, the modern research literature and foreign literature on the treatment of psoriasis drugs or methods.A prospective randomized controlled trial design, research into the group of 59 patients with,56 cases completed, which Lithospermum cream (test group completed 29 matrix ointment control group 27 cases completed. Treatment of patients also received oral detoxification decoction, treatment for 8 weeks every 2 weeks.Using PASI scoring method at home and abroad, the lesions of the patients before treatment, treatment for 2 weeks,4 weeks,6 weeks,8 weeks were used as the main criteria for evaluation of efficacy. At the same time, the pruritus VAS score and traditional Chinese medicine main clinical symptom index (scales, itching, dry mouth) observation of Lithospermum cream combined with nourishing Jiedu Decoction for remission of clinical symptoms of patients with symptoms and TCM.Treatment of patients with the use of the subjective feelings of the investigation, to supplement the lack of objective evaluation.To observe the drug safety, the treatment process closely observed in patients with adverse reactions. And to carry out laboratory safety testing, before treatment, after treatment for patients with blood, urine routine, liver and kidney function, ECG examination.The skin barrier function indexes were detected in the skin lesions and non skin lesions of psoriasis patients with psoriasis vulgaris, which included the sebum content, skin moisture and skin moisture loss (TEWL). Analysis of the skin barrier function in patients with psoriasis blood dryness syndrome by self contrast method. After the treatment group to test the lesional skin sebum content and skin moisture content and transepidermal water loss (TEWL), analyze and summarize the treatment of Lithospermum cream, repair of skin barrier function in lesions of patients with psoriasis vulgaris.ResultLithospermum cream (test group before treatment PASI score average 9.48±4.91, after treatment decreased from 3.45+1.89; cream base control group before treatment PASI score an average of 9.17±4.82, treated fell to 5.60±2.63. The PASI scores of the two groups before treatment were decreased, and the experimental group decreased significantly compared with the control group, with statistical significance (p<0.05). Lithospermum cream (test group 1 person cured,10 people were markedly effective,11 people, the total effective rate was 75.86%; control group 7 markedly,8 people, the total efficiency of 55.56%, between the two groups with significant difference (P< 0.05).Lithospermum cream (test group and the control group of pruritus score after treatment than before treatment decreased (P< 0.05); between the two groups after treatment pruritus score were compared, with significant difference (P< 0.05). TCM symptom improvement, two kinds of treatment methods for itching, scaling, thirsty, blood dryness syndrome characteristics have improved significantly, especially in itching relieving, scaly reduced aspects of Lithospermum cream group is better than control group (P< 0.05). There were no obvious adverse reactions in the two groups during the treatment, and no abnormality was detected before and after treatment.The end of the treatment, Lithospermum cream in the experimental group were generally believe that we provide the drug on the psoriasis treatment has indeed help; overall feeling than ever in the ointment smearing more comfortable.Psoriasis blood dryness syndrome in patients with skin lesions and non lesional site control, skin barrier function compared had significant difference (P<0.01) and non lesional skin compared to psoriatic lesional skin fat content decreased, increased TEWL, skin moisture content decreased in the control, indicating that psoriasis blood dryness syndrome in patients with lesions of skin barrier function decline. Drug intervention, two groups of skin lesions of skin oils, TEWL, skin moisture content have callback, and Lithospermum cream in the experimental group is better than control group, Lithospermum cream can better improve the psoriatic lesional dry, peeling, itching, symptoms, of psoriatic skin barrier function have good repair effect.ConclusionDrug external therapy provides a variety of solutions for the treatment of psoriasis.This study demonstrated that shikonin cream in the treatment of psoriasis vulgaris blood dryness syndrome, curative effect, high safety. Can improve the clinical symptoms of traditional Chinese medicine, the patient’s subjective feeling good.The experimental results show that the skin barrier function of skin lesions in patients with psoriasis vulgaris was severely damaged. Topical cream shikonin can effectively repair the. |
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