The Test Of Skin Barrier Function And Clinical Study Of Associated Factors On Eczema Change With Psoriasis Vulgaris

[Background and Objective]Skin is the largest organ of the human body, also is the body’s natural barrier, its physiological functions include thermoregulation, feeling, absorption, secretio and excretion, feedback and so on, the barrier function is of great significance. Psoriasis has different levels of skin barrier function in patients with varying degrees of damage. Patients with psoriasis vulgaris’lesions mainly are invasive erythema, attached in silver scales, accompanied with film phenomenon and dotted hemorrhage, Auspitz (+), some patients’lesions show with scratches, blood scab skin, scales from white to pale yellow to dark brown color because of the stimulationsuch as pruritus scratch, that is associated with eczema clinical manifestations.This clinical research focused on the skin barrier of patients with psoriasis vulgaris and its changes in skin rashes on sample situation investigation and analysis, the skin barrier function is impaired in patients with psoriasis vulgaris.We study the differences of skin barrier and related indicators between lesion area and non-lesion aera of psoriasis vulgaris patients,patients and healthy people;In addition,we did some investigations and analysis about skin lesions with eczema change from patients with psoriasis,to investigate the incidence and related factors of the psoriasis vulgaris patients with eczema appearrance. [Methods and Results] Part one:The clinical analysis of skin barrier function of patients with psoriasis vulgaris.We use the skin barrier function tester to get the skin stratum corneum moisturecontent,PH and transepidermal water loss(TEWL);We make use of the clamp method and spectrophotometry to get levels of serum NO and serum VitE from 30cases of patients with psoriasis vulgaris and 34 cases of healthy people. We found that patients with psoriasis vulgaris’lesions area PH value is (5.69+0.61),it issignificantly higher than the non-lesions area as well as healthy people;Lesion area’s water content is(17.90 ±6.75),it is significantly belower than the non-lesion area as well as healthy people;The TEWL of non-lesion area is (18.58±11.55),significantly higher than the lesion area and healthy people;However.there is no statistically significant difference between non-lesion area and healthy people on PH、TEWL and water content.Psoriatic lesion area in patients with adanced,the water content is (18.28±7.51),higher than that of stationary phase, statistically significant;Receding water content is(21.64±5.28),higher than that of stationary phase,statistically significant;Stage receding water content is higher than the progress, but no statistical difference;Advanced TEWL value is (22.74 ±13.16) g/m2h,higher than fade stage, statistically significant;The TEWL value in advanced stage is higher than that of stationary phase,without statistical difference;The TEWL value inresting stage is higher than fade stage,without statistical difference;PH value has no statistical difference between active stage、resting stage and fade stage.Patientswith psoriasis vulgaris’VitE is7.27±0.96ug/ml,which is significantly lower than healthy people,patients with psoriasis group’s NO is5.29±1.91 umol/L,which is significantly higher than healthy people. Part two:The clinical analysis of eczema change of patients with psoriasis vulgaris.We established statistical scale and used the image acquisition equipment to record the basic information and gross and microscopic lesion; The SPSS 16.0 software and Excel software were made use for data analysis.The results are as follows:The 241 cases of patients with psoriasis vulgaris included 137 male cases and 104 female cases. A total of 122 cases of patients with eczema appearance change, the rate was 50.6%, this change of patients in gender, age, family history,course of diseases, season has no statistically significant differences; However,theskin type, different degree of pruritus and disease staging difference are statistically significant.[Conclusions]1.Patients with psoriasis vulgaris,on their lesion area,the indicators of skin barrier function are abnormal,compaired with non-lesion area and health group,the skin PH value becomes higher,corneous layer water content becomes lower,TEWL value becomes higher,Serum VitE becomes lower and Serum NO becomes higher.We need to restore the skin barrier function in patients with psoriasis during the treatment.2.Patients with psoriasis vulgaris have strong itching feeling or have dry skin, or they are in progressive stage,the skin lesion will be easier to have eczema-change.In the early treatment,the itching drugs and humectant should be paid greatly attention to.The medicine should be used jointly to improve curative effect,also to promote skin lesions disappeared.