Association To Personality Between The Serotonin And Norepinephrine Transporter Genes Polymorphisms

Objective To assess the association to the Eysenck personality Questionnaire (EPQ) personality among Stin2,5-HTTLPR,NET T-182C,NET G-1287A in the Chinese Han normal population.Methods 367 unrelated Chinese Han healthy people were selected with strict standards, general demography data were collected, three personality dimensions (Neuroticism, Extraversion and Psychoticism) were assessed with EPQ, calculate the standard scores (T) of three dimensions, and then divide the personality into two levels by the T50: Neuroticism and Non-neuroticism, Introversion and Extraversion, Psychoticism and Non-psychoticism;Using the polymorphism of Stin2,5-HTTLPR,NET T-182C and NET G-1287A were detected by polymerase chain reaction (PCR). SPSS13.0 software were used for single polymorphism association analysis: Personality means were compared with t -test and One-Way ANOVA,the genotype and allele frequency distribution were compared withχ2 analysis; UNPHASED software were used to calculate Global P; MDR Software were used to perform gene-gene interaction analyze among Stin2,5-HTTLPR,NET T-182C and NET G-1287A.Results:1. Hardy-Weinberg equilibrium testStin2,5-HTTLPR,NET T-182C and NET G-1287A were obtained Hardy-Weinberg equilibrium (P>0.05), which indicated that the sample can represent the population.2. 5-HTT gene polymorphism and personality2.1 Stin2①There was no statistically significant difference of each personality means between different Stin2 genotype and allele frequency(P>0.05).②There was no statistically significant difference of Stin2 genotype and allele frequency distribution between different personality dimension levels(P>0.05).2.2 5-HTTLPR①The mean T scores of N latitude's have statistical significance among L\S allele(t=2.232,P=0.026),subjects with L allele showed more neurotic personality(46.26±10.19) than subjects with S allele(44.02±10.89). There was no statistically significant difference of other personality means between different 5-HTTLPR genotype and allele frequency(P>0.05).②There was no statistically significant difference of 5-HTTLPR genotype and allele frequency distribution between different personality dimension levels(P>0.05).3. NET gene polymorphism and personality 3.1 NET T-182C①The mean T scores of E latitude's have statistical significance among T\C allele(t=-2.680,P=0.008),subjects with C allele showed more extroversion personality(60.53±9.06) than subjects with T allele(58.33±9.99). There was no statistically significant difference of other personality means between different NET T-182C genotype and allele frequency(P>0.05).②There was no statistically significant difference of NET T-182C genotype and allele frequency distribution between different personality dimension levels(P>0.05).3.2 NET G-1287A①The mean T scores of P latitude's have statistical significance among G\A allele(t=-3.226,P=0.001), subjects with G allele showed lower psychoticism personality(46.49±8.77)than subjects with A allele(48.90±9.02). There was no statistically significant difference of other personality means between different NET G-1287A genotype and allele frequency(P>0.05).②The NET G-1287A genetype(χ2=9.950,P=0.007) and allele(χ2=9.644,Pearson P=0.002,Global P=0.003,OR=2.275) distribution have statistical significance between Introversion and Extraversion,GG genetype frequency(72.6%) and G allele frequency(85.5%) were significantly high among introversion subjects. The NET G-1287A allele distribution have statistical significance between Psychoticism and Non-psychoticism(χ2=4.456,Pearson P=0.035,Global P=0.035,OR=0.694), G allele frequency(76.0%) was significantly high among non-psychoticism subjects.4. There were no significant interaction among Stin2,5-HTTLPR,NET T-182C,NET G-1287A.Conclusions:1. The Stin2 gene polymorphism may have no association with the Neuroticism, Extraversion and Psychoticism personality in the Chinese Han normal individuals.L allele of 5-HTTLPR have associations with N latitude.2. T allele of NET T-182C have associations with E latitude. NET G-1287A have associations with E and P latitude. G allele is the doubtful risk factor of introversion personality and have associations with P latitude.3. Not yet found the interaction to the personality among Stin2,5-HTTLPR,NET T-182C,NET G-1287A in the Chinese Han normal population.