Analysis Of Prognostic Factors Of 198 Decompensate Hepatic Cirrhosis Patients

Objective:To study the factors influencing the prognosis of the patients with decompensate hepatic cirrhosis. Methods:198 cases diagnosed as decompensate cirrhosis were retrospectively recorded and followed up. 23 clinical and laboratory parameters were investigated as predictive risk factors for patients. 23 clinical and laboratory parameters contained gender,cause of the decompensate cirrhosis,age, aspartate amino transferase,alanine amino transferase, albumin, globulin , prothrombin time,partial thromboplastin time,fibrinogen, ascites, serum sodium, spontaneous peritonitis,hepatic encephalopathy, esophageal-gastric variceal bleeding and so on.Using Kaplan-Meier method and Log- rank test for univariate analysis and using Cox proportional hazard regression for multivariate analysis. Results: According to the univariate analysis ,15 indexes such as age , aspartate amino transferase, alanine aminotransferase, serum albumn, globulin,, prothrombin time,fibrin,ascites , sodium concentration, total cholesterol, high density lipoprotein,hepatitis b virus copy, spontaneous peritonitis, hepatic encephalopathy and esophageal-gastric variceal bleeding were related to the prognosis of the patients with decompensate hepatic cirrhosis (P<0.05). Cox proportional hazard regression indicated that aspartate amino transferase, globulin, HBV-DNA, spontaneous peritonitis,hepatic encephalopathy and esophageal-gastric variceal bleeding had had significant influence on the prognosis of hepatic cirrhosis patients(P<0.05). Conclusion:The factors which were related to the prognosis of the patients with decompensate hepatic cirrhosis were aspartate amino transferase, globulin, HBV-DNA, spontaneous peritonitis,hepatic encephalopathy and gastroesophageal variceal bleeding.