| Objective:Explore the Gu Tong Membrane on Japanese white rabbits of experimental osteoarthritis of the knee of serum superoxide dismutase (SOD) content and hyaluronic acid (HA), a nitric oxide (NO) content in., For the next film can be in the clinical treatment of pain of osteoarthritis of the knee to promote and provide experimental basis and theoretical basis.Methods:The experiment with ligation of Japanese white rabbits right lower limb femoral vein of the approach to building large-ear white rabbit model of osteoarthritis of the knee, Gu Tong Membrane through the external application of the method of pain treatment, Recognized for external use of the relatively Tongluo Qutong Film the results were compared the efficacy of, Will be 30 Japanese white rabbits were randomly divided into normal group, model group, (treatment group)Gu Tong Membrane group, (control group) Tongluo Qutong Film groups, matrix groups, In addition to the normal group, the other groups were of Japanese white rabbits underwent right lower limb femoral vein ligation method of modeling. After 8 weeks of modeling, The treatment group were treated with Gu Tong Membrane topical treatment, control group Tongluo Qutong Film treatment, matrix group were treated with Matrix Plaster treatment. Treatment for 3 weeks after taking blood and serum superoxide dismutase (SOD), hyaluronic acid (HA) and nitric oxide (NO) content. SPSS13.0 statistical analysis of data using software processing, line t test was used for statistical analysis.Results:Making module serum SOD levels compared with normal group decreased significantly (P<0.01), tests used in the present modeling approach is successful. SOD content in the treatment group compared with the model group (P<0.01), Compared with normal group(P>0.05). Treatment group compared with the control group no significant difference in SOD content (P>0.05). Description Tongluo Qutong film and Gu Tong Membrane have increased the role of SOD, SOD Matrix ointment content of serum in the normal group decreased significantly(P<0.01), Help to improve the SOD Matrix ointment showed no significant effect.Making module serum NO levels compared with normal group increased significantly (P<0.01), tests used in the present modeling approach is successful. NO content in the treatment group compared with the model group (P<0.01), Compared with normal group(P>0.05). Treatment group compared with the control group no significant difference in NO content (P>0.05). Description Tongluo Qutong film and Gu Tong Membrane have decreased the role of NO, NO Matrix ointment content of serum in the normal group increased significantly (P<0.01), Help to improve the NO Matrix ointment showed no significant effect.Making module serum HA levels compared with normal group increased significantly (P<0.01), tests used in the present modeling approach is successful. HA content in the treatment group compared with the model group (P<0.01), Compared with normal group(P>0.05). Treatment group compared with the control group HA significant difference in HA content (P>0.05). Description Tongluo Qutong film and Gu Tong Membrane have decreased the role of HA, HA Matrix ointment content of serum in the normal group increased significantly(P<0.01), Help to improve the HA Matrix ointment showed no significant effect.Conclusions:Gu Tong Membrane can improve the Japanese white rabbits of knee osteoarthritis in blood SOD activity, To reduce the content of HA and NO, Suppression of oxygen free radicals on the cartilage cells and matrix damage, Articular cartilage to improve blood circulation, Thus play a protective effect of articular cartilage, and thus prevention and treatment of knee osteoarthritis.
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