| Objective: To compare the predictive accuracy of"hot spot"relative cerebral blood volume(rCBV)method and pathological grading in the short-term (1~2 years) progression-free survival of high-grade astrocytoma patients by using Meta analysis.Methods: Literature search in PubMed and CNKI was firstly conducted, then we collect the four-frame information of rCBV and pathological grading in predicting the 1 year (2 year) progression-free survival from the included studies. Statistical analysis which aiming getting the summary sensitivity TPR*(true positive rate)and graphing are all conducted by the software SAS 9.1.Results: The accuracy of"hot spot"rCBV method and pathological grading in predicting the 2 year progression-free survival (TPR*0.70~0.78) are all higher than that of predicting the 1 year progression-free survival (TPR*0.66~0.73). In 1 year progression-free survival prediction ,the"hot spot"method summary sensitivity TPR* (0.70623±0.03830,0.69435±0.04186, 0.66708~0.72212 ) conducted by least squares method, weighted least squares method and robust method are all higher than that conducted by pathological grading (gradeⅢand gradeⅣ) TPR*(0.66157±0.05278 ,0.64296±0.12492 , 0.64794~0.69211). In 2 year progression-free survival prediction , the"hot spot"rCBV method TPR* conducted by weighted least squares method (0.74087±0.02852) is much higher than that of pathological grading (0.65553±0.07945). The"hot spot"rCBV method TPR* conducted by least squares method and robust method (0.70905±0.03777 , 0.74077~0.75676) are both slightly lower than that of pathological grading (0.73094±0.10019, 0.75306~0.77556). Conclusion: In the high grade astrocytoma short-term (1~2 years) progression-free survival prediction, the accuracy of PWI's regional high rCBV value is the same as that of pathological grading (gradeⅢand gradeⅣ), and it is even more accuracy in 1 year progression-free survival prediction.
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