| 1. Objective:To evaluate Heart-Protection Musk Pill on experimental rat model of myocardial infarction ventricular remodeling in rats.2. Methods:In this study, ligation of left anterior descending coronary artery caused acute myocardial infarction model, comparative observation of proprietary Chinese medicines with Western drug HMP captopril rat model of myocardial infarction and ventricular remodeling by angiotensinâ…¡, brain natriuretic peptide and HMP improve ventricular remodeling mechanism has been discussed, while exploring the size of the dose of HMP on Rat ventricular remodeling with or without different.60 SD rats were completely randomized, pre-9 as control group, the remaining 51 rats through the junction of left anterior descending coronary artery caused acute myocardial infarction model, The model was successful 36 rats were randomly divided into four group, model group, dose Shexiangbaoxin balls, HMP high dose group, captopril group, n= 9. In addition to keeping control group not often that any intervention; model group fed once a day, to the calculation of normal saline by 1ml/100g; Heart Heart-Protection Musk Pill (HMP)dose modeling in myocardial infarction 2 days after the beginning of each day to Musk Pill 1.16ml/100g (6.75mg/ml),1 times/day; HMP modeling high-dose group until day 2 days to HMP 1.16ml/100g (20.25mg/ml),1 times/ day; captopril tablets group modeling in myocardial infarction 2 days before tablets a day for captopril solution 1.1ml/100g (5mg/ml),1 times/day; Weighed in each group after 1 week after dose adjustments when fed to drawn. All because of anesthesia accidents, trauma and other causes of death and survival time after time requirements have not yet drawn up the animals, the observed test statistics are not included within the scope of the project. After the modeling, the rats were observed daily general life circumstances such as:mental health, hair, diet, water intake, activity and reaction degree. To be given medicines at least 2 weeks, hemodynAMIc parameters measured in rats using ELISA, the plasma brain natriuretic peptide (BNP), plasma angiotensinâ…¡(Angâ…¡), angiotensin AT1, AT2 receptor antibody levels that left ventricular weight and divided by its weight, calculated left ventricular mass index, ischeAMIc area were taken and the non-ischeAMIc myocardium, HE staining and Masson staining under light AMIcroscopy and immunohistocheAMIstry, and by transAMIssion transAMIssion electron AMIcroscopy observation.3. RESULTS:The results showed that Heart-Protection Musk Pill of high-dose, dose and captonpril after AMI can improve the lives of the general situation and hemodynAMIcs, AMI can improve rats after a series of myocardial tissue ventricular structure and organization of pathological changes to reduce non-infarcted area after AMI collagen content increase can be reduced after AMI AT1 receptor in rats and increased AT2 receptor, improve ventricular remodeling after AMI. Heart-Protection Musk Pill of high-dose rat in improving AMI cardiac contractile function of the indicators of effective than Heart-Protection Musk Pill dose and captonpril; to improve cardiac diastolic function, Heart-Protection Musk Pill of high-dose, dose, the effect of captonpril the difference was not statistically significant.4. Conclusion::HMP large doses, such doses inhibited after myocardial infarction in rats activation of renin-angiotensin-aldosterone system, improve hemodynAMIcs, thereby reducing myocardial infarction and surrounding pathological changes of the myocardium and reduce cardiac local and circulating Angâ…¡, AT1 receptor and AT2 receptors increases achieved. Model of acute myocardial infarction on neuroendocrine function and regulation of angiotensin converting enzyme inhibitor (ACEI) were siAMIlar, reduce ventricular remodeling in rats.
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