| Objective1.Collecting Chinese medicine research literature, looking for the the cause and mechanism of radiation-induced salivary and the distribution law of syndrome type, analizing the using trends in Chinese herbs, and exploring effective treatment of this disease.2. Observing the changes of radiation-induced xerostomia symptoms in patients, to understand the prevention of radiation-induced sialadenitis with that by the clinical application of HuangLianshengdi decoction.3. Observing the effect and hematology on salivary secretion by animal experiments,and understanging the mechanism of action about prevention of radiation-induced salivary with HuangLianshengdi decoction,from the microstructure,to provide a theoretical basis in treating radiation damage with Chinese medicine.Methods1.Searching on VIP and CNKI network for the medical academic articles about radiation-induced sialadenitis in 1990-2010, in which describe the Chinese syndrome type of the disease, analysize their laws of differentiation syndrome type and Chinese herbs uses.Developing clinical signs and syndromes observed table,collecting four diagnostic information in patients,establishing an information-based syndrome type data.2. Clinical research:30 cases patients that scheduled for radiotherapy of head and neck cancer were divided into 2 groups:MR and RG. MR group since the beginning of radiotherapy to take until the end,Huanglianshengdi decoction day 1, morning and evening hours service. RG group did not receive medicine and salivary protective drug, side effects such as radiation therapy appears to give symptomatic treatment. Two groups were in the end of treatment before radiotherapy and radiotherapy underwent salivary gland function tests.3. Animal experiment:28 New Zealand rabbits were randomly divided into Medicine and radiotherapy group (8 cases, administered orally with HuangLianshengdi decoction and radiotherapy,MR), Amifostine and radiotherapy group (7 cases, administered orally with amifostine and radiotherapy,AR), radiotherapy group (7 cases, administered radiotherapy,RG), blank group (6 cases,BG). MR are administered orally with HuangLianshengdi decoction from 3 days before irradiation to 3 days after radiotherapy. AR are administered with amifostine 200mg/m2 intraperitoneal injection 30 minutes before radiotherapy given. RG are not administered before radiotherapy. Each group 3 days before radiotherapy and radiotherapy,1 day and 3 days after,to take blood and salivary gland imaging line. Animals 3 days after radiotherapy uniform were killed, parotid gland tissue for pathological testing.Results1. Salivary gland radiation damage our dialectical law of classification and medication summary:asthenic yin causing excessive pyrexia, Yinxuhuodu and Reduzhisheng are the main type of radiation-induced sialadenitis,84%, and have established YangYinShengJin Qingrejiedu treatment。2. Clinical research:MR radiotherapy patients at the end of white blood cell and lymphocyte counts were significantly higher than the radiation group (P<0.05), the remaining blood and liver and kidney function as compared with radiotherapy alone had no significant difference(P>0.05). Salivary gland scintigraphy before and after radiotherapy that MR was significantly higher than the radiotherapy group, protective effect of salivary gland cells3. Animal studies confirmed:HuangLianshengdi decoction pair of radiotherapy in patients with white blood cells, lymphocytes can protect, and no effect on the liver and kidney function. Salivary gland scintigraphy showed HuangLianshengdi decoction on experimental rabbit salivary glands uptake and excretion function of impact, come to HuangLianshengdi decoction can improve the radiation damage,and repair radiation damage of salivary gland function.Conclusion1.Toxins intrinsic radioactive main pathogenesis of intestinal injury. Yinxuhuowang, Yinxuhuodu and Reduzhisheng are the basis of syndrome type. YangYinShengJin Qingrejiedu is the primary treatment.2. Modified HuangLianshengdi decoction could improve symptoms and signs of radiation-induced sialadenitis without any side effects, so that patients could complete radiotherapy successfully.3. The results of the animal study showed that modified HuangLianshengdi decoction could protect intestinal mucosa and accelerate its healing from radiation damages, as well as reduce the salivary inflammatory response and inhibit endotoxin translocation, protect mechanical and immune barrier function of salivary.
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