Clinical Research On The Jia Wei Chai Ling Decoction Jointed Cisplatin And Interleukin-2 Intraperitoneal Injection Treating Hydroperitoneum In Liver Cancer

Objective:To observe the clinical effects of Jia Wei Chai Ling decoction (JWCLD) jointed cisplatin and interleukin-2 (IL-2) intraperitoneal injection in the treatment of hydroperitoneum in liver cancer, and elucidate JWCLD could ameliorate the short-term efficacy of solid tumor, quality of life, commom clinical symptom and tumor targets of patients and reduce the toxicity of chemotherapy and biological response modifier(BRM), which reveal the feature and dominance of traditional chinese medicine (TCM) on hydroperitoneum in liver cancer.Methods:Using randomized controlled methods of observation of 40 cases of hydroperitoneum in liver cancer patients, divided into JWCLD+intraperitoneal therapy group(treatment group) and the intraperitoneal therapy group(control group),20 cases in each group. The treatment group takes JWCLD and with cisplatin and IL-2 intraperitoneal injection, and control group are given cisplatin and IL-2 intraperitoneal injection alone. After treatment, the hydroperitoneum regression, quality of life, commom clinical symptoms, short-term efficacy of solid tumor and tumor targets changes of patients were obsereved. Besides, we also obsereved the effect of JWCLD on the toxicity of chemotherapy and BRM and analysised the differences between the two groups in the above-mentioned indicators.Results:Compared with control group, there have significant differences in treatment group in decreasing hydroperitoneum, improving quality of life, ameliorating symptoms and reducing the toxicity of chemotherapeutics. Effective rate and disease control rate in recent therapeutic effect of treatment group are higher than control group. The two groups on the impact of target tumor was no significant difference.Conclusion:JWCLD in the treatment of hydroperitoneum in liver cancer patients can reduce the hydroperitoneum, ease pain, improve physical condition; to improve patients quality of life and mitigate the common clinical symptoms; able to control tumor growth, stabilize lesions, improve disease control rate; can reduce the toxicity of chemotherapy to ensure the smooth completion of chemotherapy.