The Charge Of Plasma Homocysteine And Ventricular Remodeling In Chronic Kidney Disease Patients

Objective To explore the charge of plasma homocysteine and determine the relation-ship between hyperhomocysteinemia and ventricular remodeling in chronic kidney disease pa-tients. Methods 60 chronic kidney disease patients and 60 healthy volunteens were included in this study. Plasma total homocysteine (tHcy) levels were measured by using chemilumi-nescence method. Ventricular remodeling parameters were measured by HDI-5000 echo-cardiography. Ventricular remodeling parameters including LVDd, IVST, LVPWT, LVEF ,E/A. LVMI was calculated by established formulas. Results The prevalence of hyperho-mocysteinemia was 70% in the chronic kidney disease patients and was 5% in the healthy controls. The mean level of Hcy [(27.29±25.87)μnol/L] was significantly higher in chronic kidney disease patients than that in the healthy controls[(8.65±2.57)μmol/L](P <0.05). LVDd,IVST,LVPWT,LVMI,LVEF,E/A were significantly higher in the group of hyperhomocysteinemia in chronic kidney disease patients than that in the healthy controls (P<0.05). LVDd,IVST,LVPWT,LVMI were positively and independently cor-related with Hcy(r=0.30,0.44,0.58,0.42,P<0.05). While LVEF and E/A were neg-atively correlated with Hcy (r=-0.42,-0.45, P<0.05). Multivariate stepwise regression indicated that the correlation also existed independently of other conventional risk factors such as age, sex, blood pressure, blood lipid, hemoglobin. Conclusions (1) The prevalence of hyperhomocysteinemia was higher in chronic kidney disease patients. (2) Hyperhomo-cysteinemia may be an independent risk factor in chronic kidney disease patients that affects ventricular remodeling.