| Bankground and Objective:As the final phase of the development of cardiovascular disease, heart failure has aroused people’s concern. Left ventricular mass index is a improtant indicator of ventricular remodeling, which is the main pathological mechanism of heart failure. In recent years, a growing number of studies have shown that homocysteine participate in the process of heart failure, and it is closely related to the prognosis of that. By studing plasma homocysteine level, left ventricular mass index, six months for worsening heart failure readmission and all-cause death incidents in elderly patients with heart failure, this study is aimed to observe the correlation between homocysteine and left ventricular mass index, meanwhile, it is also to explore the relationship of homocysteine and short-term prognosis of elderly patients with heart failure.Methods: According to the inclusion and exclusion criteria, 93 patients, with complete clear diagnosis of heart failure, were choosed as a subject of the study who were in the endocrine department from the Third clinical medical school of the Jilin University from January 2015 to December 2015, male: 40 cases, female 53 cases, aged: from 60 to 79, average age : 69.79±5.88 years old. And other 90 health subjects after examination served as control group, male: 49 cases, female 41 cases, aged: from 60 to 76, average age: 67.43±4.75, the control group subjects were choosed from our hospital physical examinationers. Records patient’s general condition including age, gender, weight, height, history of hypertension and diabetes and smoking. Detection of patients with fasting Hcy,NT-pro BNP, FPG,Scr, TC, TG and LDL-C levels within 24 hours after admission. All patients were also accept doppler ultrasonic testing on LVEDd, IVST, PWT, LVEF ect. And the left ventricular mass(LVM) was calculated according to the Deiereux formula. The incidents of readmission due to heart failure become more serious and all-cause death were recorded within six months. All statistics analyzes were performed using SPSS21.0 statistical software package for analysis. Continuous variables were presented as means±standard deviations(??±s), the unpaired student’s t test was used to compare the data between the two groups. The count datas were said to rate or frequency, using chi-square test.Relationships between variables were assessed using Spearman correlation analysis. A value of P<0.05 was considered statistically significant.Results: Mean plasma Hcy level was higher in the heart failure group than in the control group(P<0.05),and it increased gradually as the deterioration of cardiac function.What’s more, LVMI of patients with heart failure presented similar change as the increase of New York Heart Association classification.Plasma homocysteine level of man was higher than that of feman in elderly people(P<0.05).We also found that the level of homocysteine was positive related to NT-pro BNP in group of heart failure(r=0.306,P=0.005).However, there were no statistically significant difference about the event rate of worsening heart failure readmission and all-cause death within six months between group A and group B(?2=0.410,P=0.522;?2=0.097, P=0.755).Conclusions:1.In elderly people, plasma Hcy level was significantly higher in patients with heart failure. And it increased gradually with the deterioration of cardiac function.2. Plasma homocysteine level of man was higher than that of feman in elderly people.3.Plasma Hcy level and LVMI were rising as the increasing of New York Heart Association classification. Which suggested that Hcy may promote the occurrence of heart failure by panticipating in ventricular remoding in elderly patients with heart failure.4.Plasma Hcy level can not predict the short-term prognosis effectively in elderly patients with heart failure. |
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