Different Types Of CG Intravesical Irrigation Bcg's Clinical Observation

Objective:Through the compare of postoperative recurrence of Cystitis Glandular by Bacillus Calmette-Guerin Intravesical Irrigation in different clinical types, estimating its curative effect on preventing postoperative recurrence and the probability of side-effect.Methods: 83 pathologically proved Cystitis Glandular patients by TURP were randomly divided into 2 groups. Group 1: 49 cases (2 lost)were carried out Bacillus Calmette-Guerin Intravesical Irrigation after transurethral electroresection(44 cases). 5 cases of mucosa without changing without surgery , 120mg BCG and 50ml NS are instilled into bladders once a week one week after the operation. This treatment will last for 8 weeks. After this, this treatment will last for another 10 months by 1 instillation per month. Group 2: 27 cases (5 lost),24 cases were not subjected to any drug after operation. 3 cases of mucosa without changing were followed up without surgery, Then compare the probability of postoperative recurrence and side-effect of the 2 groups. Results: At a medical follow-up of 12-36 months(28.8 months on average), 8 cases recurred in Group 1, the percentage of recurrence is 16.3%, among which 4 cases of follicular, the percentage of recurrence is 15.4%,3 cases of papillarytumor, the percentage of recurrence is 27.3%,1 cases of chronic inflammation, the percentage of recurrence is 14.3%,no recurrence of mucosa without changing. The cure rates for each type is 84.6%,72.7%,85.7% and 1 separately. 11 cases recurred in Group 2, the percentage of recurrence is 40.8%, among which 6 cases of follicular, 3 cases of papillarytumor, 1 cases of chronic inflammation, 1 cases of mucosa without changing were recurred. The recurrence rate for each types is 42.9%,50%,25% and 33.3% separately. There are significant differences between Group 1 and Group 2 (x22vs1 = 5.53 ; P< 0. 05 ); The recurrence rate of Follicular and papillary tumor are higher than chronic inflammation and mucosa without changing , but there has no significant difference between them. The percentage of postoperative side-effect is 40.8%(group 1).Conclusion: Transurethral electroresection combined with BCG intravesical irrigation for the treatment of cystitis glandularis can significantly decrease the recurrence of cystitis glandularis . The method is worth being widely used. The recurrence rate of Follicular and papillary tumor type are higher than chronic inflammation and mucosa without changing , but there has no significant difference between them. This may concerned with the insufficient samples of this research. Through the way of taking Isoniazid orally one day before every BCG intravesical irrigation and last for 3 days, the occurrence of side-effect could be reduced.。...