Research On SVCAM-1 Levels In SSHL

OBJECTIVE1. Test the serum sVCAM-1 level of SSHL patients.2. Compare the sVCAM-1 levels of SSHL patients with different conditions.3. Approab the possible pathogenesy that sVCAM-1 caused in SSHL.METHODSThe serum level of both SSHL group and contrast group(healthy people)were tested by ELISA.Accroding to sex,age,degree of hearing loss,smoking,drinking,habits,history of upper respiratory infection and cardio- cerebrovascular complications,the SSHL group was dividede into different groups.SPSS17.0 software was used to compate the data,t-test and one–way ANOVA methods were used to compare sample.RESULTS1. The serum sVCAM-1 level was higher in SSHL group compared with contrast group(p<0.0001).2. The serum sVCAM-1 level was higher in the elderly group than younger group (p<0.05).3. The serum sVCAM-1 level was higher in group with the upper respiratory infection than those who without infection(p<0.05).4.The serum sVCAM-1 level was higher in group with cardio-cerebrovascular complication than those who without (p<0.05).5. The serum sVCAM-1 level was no significant difference in groups with different sex,degree of hearing loss,habit,smoking history or drinking history(p>0.05). CONCLUSION1. sVCAM-1 may participate in the devolopment of SSHL.2. The serum sVCAM-1 level were affected by age,upper respiratory infection history and cardio-cerebrovascular complication.3. Sex,degree of hearing loss,smoking,drinking,habit had no significant effect on sVCAM-1 level.