Yi Qi Wenjing Tong Luo Fang Temperature Control By Chemotherapy With Oxaliplatin In Patients With Peripheral Nerve To Xicity Induced By Clinical Research

Purpose:Temperatures observed by Yi qi wen jing Tong Luo Fang on oxaliplatin in patients with gastrointestinal cancer program of chemotherapy-induced peripheral neurotoxicity in the clinical efficacy of combination of Chinese and Western medicine prevention and treatment of chemotherapy-induced peripheral neurotoxicity of methods and their practical significance.Methods:1 63 cases included in the effective cases, the patients met the inclusion criteria were randomly divided into two simple groups, treatment group 32 cases,31 cases in control group, two groups of patients in gender, age, pathological type, clinical stage and general status was no comparison significant difference (P>0.05), with comparable.2 Two groups of chemotherapy schemes are that sand of favourable platinum scheme is:L-OHP 130mg/m2, instils 2h intravenously, the 1st day, CF 200mg, instils 2h photophobically and intravenous, on days 1-5,5-Fu 500mg/m2, instils 6h intravenously continuously, on days 1-5, It is a cycle in 21 days. Two group offer, ask alkane department vein,5mg of Joan, instil half an hour, treat group begin, take benefit temperature by put through to hold the side in place with a net 2 day before chemotherapy before the chemotherapy,1 pharmaceutical/day, water fry clothes, divide, take twice, morning and evening respectively once, until chemotherapy is over, amounts to seven days, the control group offers reducing type glutathion 1.8g in chemotherapy on the same day, the vein is instilled, until chemotherapy is over, offer general amine 20mg skin note of first oxygen chlorine when it is sick, vomit that two groups of patients presentâ…¢degree.3 Observe 6 cycles continuously. Begin to record to this cycle to over from chemotherapy sun. Through incidence and severity that chemotherapy accomplishment ratio, peripheral nerve observing the group and control group are malicious, to judge the result of clinical application; Until CD4, CD8, CD4/CD8, NK cell change of activity find out about the impact on immunological function compare two group treat; Through observe two group physical change of weight treat, liver renal function and change of electrocardiogram come security to judge clinical application.Result:1 Treat group six cycle chemotherapy accomplishment ratio for 100% (32/32), higher than 96.8% control group (30/31), but two group comparative difference have statistics meaning.2 Of chemotherapy-induced peripheral neuropathy clinical comparison:two cycles, the toxicity of traditional Chinese medicine group was less than the control group, but P>0.05, no significant difference in possible reasons for the neurotoxicity of oxaliplatin is cumulative dose, does not appear in the short term.4 cycle, in particular, six cycles of oxaliplatin neurotoxicity gradually increased, particularly in the control group, with the dosage increased to increase the toxicity of oxaliplatin, indicating the relevance of toxicity and dosage, while the treatment group there was no significant correlation. 6 cycles of treatment group, oxaliplatin neurotoxicity caused by the overall incidence of 18.8% in the control group the overall incidence of 37.8%. The chi-square test, P<0.05, that the difference was statistically significant. To sum up, illustrate the application o3 uced neurotoxicity caused by oxaliplatin incidence.4 Two groups of patients before and after treatment comparison of immune function:After treatment:NK cell activity in the treatment group than in the control group increased, compared with theatment group CD8 decreased the control group, the difference There was a significant (P<0.05); treatment group CD4/CD8 increased to reduce the control group, the diff control group, the difference was significant (P<0.05); tre erence was significant (P<0.05).5 The two groups before and after treatment in patients with physical changes in body weight compared:Two patients with physical status (Karnofsky) and body weight were decreased; physical condition after chemotherapy in the treatment group significantly better than the control group (P<0.05), body weight slightly higher than the level of However, there was no significant difference (P>0.05).6 Two groups of patients after chemotherapy toxicity comparison: After treatment, both groups liver and kidney function in patients with ECG changes of no statistical significant difference (P>0.05).7 Two groups of patients with short-term effect after chemotherapy compared:no significant difference between the two groups (P> 0.05).Conclusion1 YiQiWenjingTong Luo Fang side of oxaliplatin induced peripheral nerve toxicity, especially peripheral accumulation of delayed neurotoxicity obvious therapy.2 YiQiWenjingTongLuoFang order to raise the patient's immune capacity3 YiQiWenjingTong Luo Fang side can improve the general condition of patient4 YiQiWenjingTongLuoFang side toxic side-effects, does not affect the efficacy of chemotherapy drugs...