| ObjectiveHubei hospital of TCM collected 60 case in CKD3 to practice a randomized, double-blind,controlled trial,to observe the effect chinese medicine,benazepril and chinese medicine combined with benazepril in treating stage 3 CKD, and to provide the basis for evidence-based medicine.MethodFrom June 2008 to December 2008,we included 60 cases with primary glomeru-lopathy and CKD3.They were randomly divided into three groups:chinese medicine group (A group,chinese medicine+Benazepril simulation),benazepril group (B group, benazepril+chinese medicine simulation) and combined group (C group,chinese medi-cine+Benazepril).According to TCM syndromes of the patients, who they could be divided into four parts, deficiency of the kidney-qi-yin(blood),kidney-collateral blood-stasis, harass with wind-dampness and damp-heat brewing internally,The therapy is r outine treatment combined with relevant treatment of TCM.The scores of TCM syn-dromes and laboratory index were observed at 0,2nd,4th,8th,12th,16th,20th,24th weeks.Result1. At the 24th week, Scores of TCM syndromes of three groups is significantly decreased comparing with 0 weeks (P<0.01);Among three groups,scores of TCM syndromes of C group fell the most obvious, which compared with A group and B group (P <0.05).2. 24h urinary protein of A group and B group is increased more than before the treatment, especially A group, but there is no significant difference between them (P> 0.05); in the 12th week,A group and B group are significant differences compared with C group(P<0.05); in the 24th week, A group and B group were not significant difference (P >0.05),but compared with C group, there is a significant difference (P<0.05).3. With the prolongation of the course of CKD,HGB of the three groups is decreased more than before the treatment group and C group is significant difference (P<0.05),A group was no significant difference comparing with before the treatment.4. Among three groups,serum UA has declined,especially,C group compared with before the treatment, there is a significant difference (P=0.06).5. In the 16th week, B group and C group compared with the A group in ALB, the difference was significant (P<0.05). ALB of C group and B group are higher than before the treatment, the difference was significant (P<0.05), A group is no significant difference after the 24th week (P>0.05)6. BUN of B group is higher than before the treatment, the difference was significant (P<0.05); in 4th,16th,20th,24th week,B group compared with A group and C group,the difference was significant (P<0.05); Cr of A group and B group are smaller than before the treatment in there is no statistical significance; B group increased compared with before treatment in Cr, the difference was significant (P<0.05).7. In the 8th,12th,16th,20th week, B group compared with CM in egger, the difference was significant (P<0.05); Among three groups egger is no significant difference. comparing with before the treatment.8. In the 12th week, among three groups, clinical effect of TCM therapeutic and Western Medicine were no significant differences (P> 0.05).In the 24th week,among three groups, clinical effect of Chinese medicine and Western medicine were a significant difference,especially, C groups.9. In adverse events,1 patients appeared cretonne doubling in C group.Among three groups,anemia is the highest.In other adverse events,A group is the highest about leucopenia,C group is the highest about hyperkalemia. Conclusion1. Among three groups,symptoms is improved,especially,C group is the most obvious.2. C group can reduce the 24h urinary protein than the individual benazepril or Chinese medicine.3. Benazepril can cause a decline in HGB, it can be stabilized at normal levels in C group.4. C group or B group can increase the level of ALB.5. C group can reduce the UA, BUN, Cr, and maintain GFR stability, so as to delay the progress of renal function.6. Shortcomings of this article is that only some patients had renal biopsy, it is not possible to judge the effect of pathological.
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