A Study For The Expression Of STAT2 And STAT3 In Cervical Cancer

ObjectiveTo investigate the expressions of STAT2 and STAT3 in cervical squamous cell carcinoma (CSCC) and its significance.MethodesPathological verified,28 CSCC,34 normal cervix (NC)and 74 cervical intraepithelial neoplasia(CIN) were detected for the expression of STAT2 and STAT3 by immuno-histochemical SP(Streptavidin Perdcidase) method.Results1.The positive expression rates of STAT2 were 27.3%,22.2%,8.7% in CINⅠ,CINⅡ,CINⅢ, respectively. There was not significantly difference between the different groups (p>0.05). The positive expression rates of STAT2 were 47.1%,20.2%,10.7% in NC,CIN, CSCC, respectively. The positive expression rate of STAT2 in different groups was significantly different (p<0.05). The expression of STAT2 was significantly lower in NC than in CIN and CSCC (p<0.05)2. The positive expression rates of STAT3 were 51.5%,66.7%, 91.3% in CINⅠ,CINⅡ,CINⅢ, respectively. There was significantly difference between the different groups (p<0.05). STAT2 expression was significantly higher in CINⅢthan in CINⅠ(p<0.05). The positive expression rates of STAT3 were 51.5%,66.7%,91.3% in NC,CIN, CSCC, respectively. There was significantly difference between the different groups (p＜0.05).The expression of STAT2 was significantly higher in CSCC than in NC and CIN (p＜0.05); higher in CIN than in NC.3. There was no correlation between the expression of STAT2 and STAT3 in CSCC (r=0.096, P=0.627).Conclucions1. STAT2 and STAT3 are expressed in NC,CIN and CSCC.They were involved in the carcinogenesis of CSCC,otherwise,STAT3 is correlated with the progression of CSCC.2. The roles of STAT2 and STAT3 in the carcinogenesis of CSCC have no correlation.