Comparison Optimal Pressure Between Automatic Titrating And Predicting Continuous Positive Airway Pressure For Patients With Sleep Apnea Hypopnea Syndrome

Objective： Optimal continuous positive airway pressure (CPAP) level reducedexcessive daytime sleepiness and improved healthy status for patients with obstructivesleep apnea syndrome. Choosing Optimal Pressure is the foundation of effectiveCPAP long-term treatment．Before accepting long-term CPAP treatment need todetermine the optimal pressure, this process is called the "pressure titration".Thepurpose of this study is to compare the differences between the automatic CPAPtitrating pressure levels (ACPAPL) and the predicting CPAP pressure levels(PCPAPL), and further analysis the influence factors of the differences.Methods: A retrospective study included96patients who were diagnosed withobstructive sleep apnea syndrome and prescribed CPAP therapy by physicians.ACPAPL as determined using automated CPAP was defined as95thper-centilespressure. The PCPAPL was calculated according to body mass index(BMI), neckcircumference (NC), and apnea/hypopnea index (AHI) formula. The paired t-test wasused to compare ACPAPL and PCPAPL. The Spearman’s correlation analysis wasused to determine the relationship between ACPAPL with leak values、BMI、NC、andAHI.Results: The mean ACPAPL (11.44±2.56) was significantly higher than the meanPCPAPL (7.02±1.61). The differences in the results were statistically significant (p <0.05). There were about87%of patients had air leaks. The ACPAPL had goodcorrelations with maximum leaks (r=0.641p<0．000),Average leak values (r=0.434p<0．000), and AHI (r=0.205p=0.046), however, the correlations with BMI (p=0.230),NC (p=0.262), and minimum leak values (p=0.733) were poor.Conclusion: The ACPAPL were higher than PCPAPL. The pressure differencesbetween ACPAPL and PCPAPL were wide. Air leaks were common during theautomatic CPAP titration. Leak value was one of the important factors that effectedACPAPL.