Study On The Effect Of Nasal Continuous Positive Airway Pressure On Interleukin-6 In Serum Of Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Purpose:To explore the change of the serum interleukin-6 level in patients with obstructive sleep apnea hypopnea syndrom(OSAHS),and to study the effects of nasal continuous positive airway pressure on interleukin-6(IL-6)in serum of patients with obstructive sleep apnea hypopnea syndrome,and to explore the protection of nCPAP to the cardiovascular system of the patients of OSAHS.Methods:Before and seven days after the therapy ofnCPAP,serum IL-6,the lowest and average SaO2 during nighttime and AHI was determined in the experimental group(n=26,AGE:49±8,BMI:29.37±1.82kg/m2)and compared with a normal control group(n=24,AGE:48±10,BMI:28.51±1.99kg/m2).Results:The level of serum IL-6,the lowest and average SaO2 during nighttime and AHI have significant difference in 2 groups(P＜0.01),Before treatment,there were significant positive correlation between IL-6 and AHI in OSAHS patients (r=0.733,P＜0.01).significant negative correlation between IL-6 and the lowest and average SaO2 during nighttime(r=-0.793,P＜0.01;r=-0.759,P＜0.01); After nCPAP(7d),the serum level of IL-6 of OSAHS patients have reduced significantly(P＜0.01).Conclusions:nCPAP can obviously decrease the level of serum IL-6 of OSAHS patients;therefore it may reduce the incidence of cardiovascular complication of OASHS patients,and protect their cardiovascular system.