The Effect Of Etomidate On The Contraction In Isolated Spontaneous Hypertension Rats Aorta

Object:The goals of our current in vitro study were to investigate the effect of etomidate on norepinephrine-induced contraction in Spontaneous Hypertension Rats (SHR) aorta and Normotensive Rat (NTR) and the cause of Hemodynamic instability on the patients with hypertension induced with etomidate.Methods:NTR and SHR each of the 18, weighting 250-350g. NTR and SHR were assigned into 4 groups:Group SHR, Group NTR, Group Control, Group Vehical. Endothelium-undenuded aortic rings were suspended for isometric tension recording. Concentration-response curves for norepinephrine (10-9 to 10-5M), were generated in the presence and absence of etomidate (5×10-6,3×10-5,5×10-5 M). In addition, the effect of lipofundin medium-chain triglyceride/long-chain triglyceride (MCT/LCT) 20%(the vehicle for etomidate), at a dose equivalent to that administered with the highest concentration of etomidate, on the norepinephrine concentration-response curve was also assessed.Results:The response of thoracic aorta to vasoconstrictor agent increased significantly in SHR. etomidate (5×10-6 M) at a clinically relevant concentration in NTR Group in vitro experiment had no significant effect on the norepinephrine-induced contraction, but had significant effect in SHR Group. In addition,in SHR Group, high dose concentration of Etomidate(5×10-5 M) had significantly attenuated the contracted extention on this aorta than NTR Group. Conclusions:That prompted that in Spontaneous Hypertension Rats, Etomidate had significant effect on the function of thoracic aorta.