| ObjectiveTo retrospectively explore clinical features and lipid /lipoprotein metabolism of severe preeclampsia women; to investigate lipids levels and LPL levels of serum and placenta in preeclampsia women; to study the relativity between hyperlipemia and LPL; to discuss the effectiveness of hyperlipemia in the pathogenesis of preeclampsia; to illuminate LPL possibly has a significant role in the pathogenesis of the case through participating in lipid abnormal metabolism.MethodsWe retrospectively evaluated clinical features of three groups which include 310 severe preeclampsia women and 300 normal pregnant women and 300 un-pregnant women in the sixth hospital of shanghai between January 2005 and May 2009; 26 cases of severe preeclampsia and 30 normal pregnant women were analyzed by experimentation. The lipids levels of serum and placentas were detected by enzymic method and oil red staining method. The LPL levels of serum were detected by ELISA. LPLmRNA and LPL protein in placentas were detected respectively by RT-PCR and Western blot.Result1. Contrasting the un-pregnant women, the lipids levels of serum, BMI, fasting blood glucose were increased significantly in the normal pregnant women. Contrasting the normal pregnant women, the lipids levels of serum, AI, BMI, SBP and DBP were increased significantly in the severe preeclampsia women. The four factors including TG and HDL and SBP and BMI were high-risk factors of preeclampsia.2. Contrasting the normal pregnant women, placentas were small in the severe preeclampsia women. Through pathological investigation, lipids were generally deposited in placentas.3. The LPL levels of serum and placenta were decreased significantly in the severe preeclampsia women compared to the normal pregnant women.4. Correlation analysis revealed that LPL levels of serum were positively related to that of placenta (r=0.421,P<0.01), and negatively related to that of serum TG (r=-0.668,P<0.05),and positively related to that of serum HDL (r=0.876,P<0.01)in the preeclampsia women.Conclusion1. The lipids levels of serum were higher, placentas developed well in the term pregnant women. These women whose atherogenic index was normal have not the risks of vasculopathy.2. The lipids levels of serum were increased significantly, and lipids were generally deposited in placentas in preeclampsia women. These women whose atherogenic index was higher significantly were high risk people who have arteriosclerosis diseases.3. The LPL levels were decreased significantly in preeclampsia women. LPL possibly has a significant role in the pathogenesis of the case through participating in lipids abnormal metabolism. |
