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Study On Bumetanide Sodium Chloride Injection

Posted on:2011-06-29Degree:MasterType:Thesis
Country:ChinaCandidate:D X SunFull Text:PDF
GTID:2154360305455019Subject:Pharmaceutical Engineering
Abstract/Summary:PDF Full Text Request
Bumetanide is a loop diuretic, that is, high diuretic drugs, mainly inhibiting me-dullary thick ascending branch of loop segment chloride reabsorption initiative, with the attendant inhibition of sodium reabsorption, and the diuretic at the same time to expand the body of small arteries, reduce peripheral vascular resistance, increased re-nal blood flow without reducing the glomerular filtration rate, is the most powerful diuretic. Through the formulation of reform, will bumetanide injection into a large infusion of water, which is characterized by fluid in clinical patients can be entered directly in vivo, does not need to dilute the role of reliable, rapid efficacy, and com-pared with the small needle to avoid wrong the risk of diluent, to protect the safety of clinical medicine. Infusion is a direct input in the human body, can avoid bacteria and other air pollution, can be more effective to ensure sterile and non-pyrogenic. and im-proving clinical drug safety. The small needle infusion should first be diluted with di-lution before dilution to be sure the amount and type of liquid. And transfusion medi-cine in clinical patients can directly enter the body, does not require dilution, small needle to facilitate clinical use, the role of reliable, rapid efficacy, but also to avoid the risk of misuse of diluent, to protect the safety of clinical medicine. Small needle with the liquid dilution, bacteria and other easily in the air pollution. The infusion is a di-rect input in the human body, can avoid the kind of situation, to reduce secondary pollution.By bumetanide and sodium chloride injection technology, quality standard and the stability of the study was the quality and stability of bumetanide infusion preparation for clinical use provides a more convenient and efficient loop diuretics.
Keywords/Search Tags:Bumetanide, Sodium Chloride, Injection, Crafts study, Quality study
PDF Full Text Request
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