| Objective: to observe Xinning Bolus shot through IL-6 serum myocardial ischemia in rats, TNF-αcontent and electrocardiogram, discusses the influence of mechanism for the clinical treatment of wide application, provide sufficient scientific theory.Methods: Wistar rats with health screening randomly divided into six groups digital method, better shot blasting low dose group ofXinning Bolus dose group of high dose group, shot through liquid group , positive control and model group, and each group of 10. Observe isoproterenol acute myocardial ischemia in ratsⅡ12-lead electrocardiography label, serum PGI2, content.Results: the Xinning Bolus each dose group, positive-controlled control can obviously reduce the content of IL-6,TNF-α, improving rats electrocardiogram ischemia. With the model group, compared with placebo P < 0.01 significant differences, heart better pills high-dosage groups.Conclusion: 1 against myocardial ischemia in rats, Xinning Bolus has good anti-myocardial ischemia effect. 2 Xinning Bolus can inhibit endothelial inflammation, protecting endothelial function, oxygen anti-myocardial ischemia. 3 Xinning Bolus each dose group can obviously make the content of IL-6,TNF-αreduce and protect the function of the blood vessel.
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