Qi Gui Decoction To Hypothyroidism Rats Experimental Study Of Thyroid Influence

Objective:observation of Qi Gui Decoction to hypothyoidism rat thyoid function,and discusses its influence mechanism.Methods:This experiment usedto60 Wistar SD rats. 6 to 7 , They were divided into 5 groups by random,the model group, the western medicine group,the chinese medicine group (high dose and low dose of Qi Gui Decoction) and the contrast group. In addition to blank group, the other four groups to propylthiouracil made model 2 weeks. After a successful give corresponding drug of eight weeks, Rats were observed before and after treatment appearance, spirit, behavior, excrement and urine, weight generally Detection thyroid function, estradiol (E₂), promote adrenal cortical hormone (ACTH), red blood cell count (RBC), hemoglobin concentration (Hb) and other indicators, and in optical microscope thyroid histopathologic morphologic changes.Results:1. rats were observed before and after treatment of symptoms, signs 2.Thyroid hormone levels after build mode is significantly below normal control group (P﹤0.05), TSH significantly higher than normal control group (P﹤0.05), sure made model success. After treatment, the treatment group, western medicine FT4 no obvious (P>0.05) change, FT3 rise compared with model group was significant difference (P﹤0.01, P﹤0.05) compared with model group, TSH are very significant difference (P﹤0.01) compared with blank group, there are no significant difference (P> 0.05).3. Model group ACTH and blank group compared significant differences (P﹤0.01), Chinese traditional medicine group group compared with blank ACTH no significant difference (P>0.05). Model group E₂ and blank group compared﹤significant difference (P 0.05), medium, western medicine therapy group group compared with blank no significant differences (P >0.05)4.Model group significantly below normal RBC and Hb group (P﹤0.01), Chinese traditional medicine group can greatly increase﹤RBC and Hb (P﹤0.05). Western medicine group significantly lower than normal control group (P﹤0.01).5. model rats pathology revealed thyroid appearance, then obviously enlargement under compensatory sex hyperplasia see thyroid organization. Traditional Chinese medicine group of organizations organ trypan-blue and performance are different degrees of improvement.Conclusions: qi gui decoction to hypothyoidism rats have good treatment effect, can not only improve their symptoms, restore serum thyroid hormone levels, but can be adjusted cause pituitary a adrenal axis and gonads shaft disorder, improve rat anemia condition, reduce pathological changes of the thyroid gland tissues and organs. treatment with pure complement mechanism, the thyroid hormone to different rats kidney and improve by yiqi influence is multifaceted.