The Effect Of Preemptive Analgesia For Postoperative Pain In Children Undergoing Tonsillectomy And Adenoidectomy

Objectives: The aim of this study was to observe analgesic effect and safety with flurbiprofen axietil, tramadol, ketamine anesthesia in children after tonsillectomy and adenoidectomy, as well as to find suitable drugs for short operation preemptive analgesia in children to reduce pediatric anesthesia of the agitation and to reduce postoperative pain relief.Methods:In this study, eighty patients(Ages 4 to 14 years old )scheduled for tonsillectomy and adenoidectomy were randomly divided into four groups ( n = 20 each ). Group F received preoperative intravenous administration of 1 mg/kg of flurbiprofen axietil at 10 min before surgery. Group K received preoperative intravenous administration of 0.5 mg/kg of ketamine at 10min before surgery. Group T received preoperative intravenous administration of 2 mg/kg of tramadol at 10min before surgery. Group C received preoperative intravenous administration 3 ml Saline of at 10min before surgery. Observed VAS score; MOPS score; circulation, respiration, oxygen saturation and adverse reactions.Results: Agitation: Group F, Group K and Group T was significiantly lower than Group C, Group F was significiantly lower than Group K and Group C. Group F, Group K,Group T VAS score and MOPS scores were significantly lower than Group C at 0h after surgery (P<0.01); Group F VAS score were significantly lower than the Group C(P<0.01)and Group K(P<0.05)at 0h and 8h after surgery, was significiantly lower than Group T at 8h after surgery(P<0.01); Group F in MOPS score lower than Group K (P<0.05)at 0h after surgery than Group C (P<0.05)at 8h after surgery; Group T VAS score lower than the Group K (P<0.05)at 0h after surgery . The incidence of postoperative sleep poor Group C was higher than Group F(P<0.05).Conclusion: Flurbiprofen axietil, ketamine, tramadol can effectively reduce agitation, but ketamine, tramadol no show effect of preemptive analgesia. Flurbiprofen axietil preemptive analgesia works well, the role of a long time, can effectively relieve postoperative pain in children, no significant adverse reactions, can be used Postoperative analgesia in children minor surgery safely.