The Formaldehyde Damages And Takes Acanthopanax The Function Experimental Study After The Movement Big Mouse's Oxidation

The formaldehyde is one kind common to the human body health danger big indoor air pollutant, it enters in the human body after the respiratory tract with the red blood cell unifies, the menstruation loop jump to the whole body each organization organ, and the rapid metabolism for the formic acid or carbon unit metabolite, the formic acid further oxidation is CO2 and the water, CO2 may pass through the lung to exhale, the part from the urine discharges by the formiate form, but its metabolite may also with the amino acid, the protein, the nucleic acid and so on form the unstable union, shifts to the kidney, the liver, the hemopoietic tissue and other organizations plays the role, affects organism function, will cause cancer. Many scholars thought that the formaldehyde inspiration may cause the mammal lipin peroxidation, has the oxidized damage function to each organization organ of organism, is one body-wide poison.Chemical composition decision on the pharmacological action of acanthopanax , it includes the sugar glucoside, the soap glucoside, the flavanone class, the polysaccharide, the trace element, the amino acid, the vitamin and so on other ingredients. At present, acanthopanax and the commodity preparation in domain applications medicine, military, health care, food is widespread. The massive research indicated that acanthopanax oxidation resistance function which and other pharmacological action with its anti-free radical oxidation related, can improve the formaldehyde to the big mouse each tissue cell's damage, enhances organism to organize the anti-free radical oxidation respectively ability.This article in the overall animal level, the simulation different density formaldehyde pollution of the environment, establishes the animal training model, the utilization physiology, the biochemistry theory and the sports biological science research technique and the technology, after different density formaldehyde gas inspiration the big mouse cardiac muscle, the brain, the lung oxidation resistance defense system's tendency change rule carries on the test analysis, the revelation supplemented that acanthopanax the solution each kind of oxidation resistance enzyme activity influence which to the movement big mouse nutritional status, the motor ability, the cardiac muscle, the brain, the lung organizes, to develop five increases taxes the plant to reduce in the indoor air the formaldehyde the harm to provide the drip reference to the human body. Experimental technique: This experiment uses healthy male in February age Wistar big mouse 64, the body weight in 180±10g, divides cage raising, all big mice the compatibility raise one week later carries on the formal training. Will test the big mouse according to the stochastic principle to divide into 8 groups, namely: the peaceful control group, the moderate formaldehyde contamination peaceful group, the specific weight formaldehyde contamination peaceful group, the pure movement control group, the moderate formaldehyde contamination add the movement group, the specific weight formaldehyde contamination to add the movement group, the moderate formaldehyde contamination to add movement acanthopanax group, the specific weight formaldehyde contamination to add movement acanthopanax group. According to the national promulgation's indoor environment concentration of contaminant standard, makes the artificial simulation varying degree formaldehyde contamination environment. The experimental group carries on the 1m3 formaldehyde pollution glass warehouse moves the type contamination, the formaldehyde contamination adds movement acanthopanax group to fill stomach 10% the solution of acanthopanax every day, for the dose is 10ml/kg, other groups fill the same volume the distilled water. The big mouse carries on under often the oxygen formaldehyde pollution of the environment runs the Taiwan training, daily 1 time, in 8:00-12:00, the speed increases progressively from 10m/min to 20m/min, the time 30 min/days, runs the taiwan slope is 0%, carries a heavy load is 0%. After five weeks contamination training had ended, beheads the execution in the 6th week 1 morning, determines each group of big mouse cardiac muscle, the brain, the lung SOD, CAT , GSH-Px and MDA , HB content.Finally: 1. Under formaldehyde pollution of the environment peaceful or movement, has the immediate influence to the big mouse body weight's growth, the specific weight pollution is bigger than the moderate pollution effect, the formaldehyde contamination movement group affects in a big way compared to the formaldehyde contamination peaceful group. Takes acanthopanax the movement big mouse body weight has the remarkable function to the varying degree contamination environment under.2. Under formaldehyde pollution of the environment peaceful or movement, the HB content change has the immediate influence to the big mouse blood, and the formaldehyde contamination movement group affects in a big way compared to the formaldehyde contamination peaceful group. But the contamination peaceful group of between HB content change does not have the difference, but the contamination environment movement group of between HB content change difference is big. Takes acanthopanax the movement big mouse's HB content has the remarkable influence to the varying degree contamination environment under.3. Under the varying degree formaldehyde pollution of the environment, the peaceful group and the movement group big mouse cardiac muscle, the brain, the lung organizes CAT, GSH-Px, the SOD activeness to have the varying degree drop, the MDA content has the varying degree rise. Namely the inspiration different density formaldehyde may cause the oxidized damage which the big mouse cardiac muscle, the brain, the lung organize, cause organism oxidation resistance ability reduces, the free radical produces massively, causes organism the lipin peroxidation. Proved that the formaldehyde may damage the big mouse free radical and the active oxygen scavenging system, and is bigger to the movement contamination group big mouse influence.4. Takes medicine the contamination movement group and the contamination movement group compares, takes medicine the group big mouse cardiac muscle, the brain, the lung to organize CAT, GSH-Px, the SOD activeness to go up, the MDA content drops. The moderate formaldehyde contamination movement group is more obvious than the specific weight formaldehyde contamination movement group effect. Showing supplemented that acanthopanax the piece to be able to strengthen the movement big mouse cardiac muscle, the brain, the lung to organize the anti-free radical oxidation defense system's function.