The Correlative Investigation Of Function Test With First-pass Perfusion CT Indexes In Patients With Chronic Obstructive Pulmonary Disease Pulmonary

Objective: To evaluate correlative investigation of chronic obstructive pulmonary disease with first-pass perfusion CT indexes . Methods: Thirty-two volunteers and thirty-seven COPD sufferers underwent MSCT perfusion imaging. The data were transferred to the ADW4.3 workstation and analyzed by the CT perfusion software, district first-pass perfusion CT indexes including time-density curve, blood flow, blood volume, mean transit time and permeability surface were measured. The correlation between the first-pass perfusion CT indexes and the parameters from quantitative PFT was assessed using Spearman correlation analysis. Results: The COPD sufferers'blood flow, blood volume and permeability surface were obviously lower than the volunteers', which had statistical significance (P<0.05).The COPD sufferers'time to peak of lung were later than the volunteers'which had statistical significance (P<0.05).The Spearman correlation test showed that the COPD sufferers'BF,BV and PS positively correlated with forced expiratory volume in 1 second(FEV1)/forced vital capacity(FVC)(P<0.05), and time to peak of lung positively correlated with FEV1(P<0.05)and FEV1/FVC%(P<0.05). Conclusion: First-pass perfusion CT indexes is helpful to the diagnosis of COPD.