Experimental And Clinical Observations On Hypoglycemic Effect Of Cavity Of Concha Stimulation

Objective: The prevalence of diabetes is significantly increased with China's economic development and changing of people's lifestyles and an aging population in China. Oral hypoglycemic agents and insulin injections are the most fast and effective way for the control of blood sugar in modern medical, However, they are often ineffective in controlling diabetic complications, especially neuropathy caused by diabetes ,and Long-term using western medicine may lead to a variety of side effects on the body and the family's economic burden. Therefore, at present, patients and clinicians are looking for an alternative therapy that is effective, convenient, cheap and low side effects for the treatment of diabetes. The purpose of this study is to find a new method for the treatment of diabetes by stimulating the cavity of auricular concha of Type-2 Diabetes Rats or Patients with diabetes, and the mechanism"ear - vagal reflex"may be a very important path for the treatment of diabetics by stimulating the cavity of auricular concha.Methods:1. The first part of the research: Separation of 10 rats form the 30 normal rats make up the control group(A) , and the remaining 20 rats were divided into the model group(10rats) (B) and the auricular acupuncture group(10rats) (C)after modeling with Chain of urine left streptozotocin. A, B without any treatment, and buried needle in the cavity of auricular concha of diabetes rats in the group C. Needle retention for 30 minutes, Bid. We detected the fasting blood glucose, glycosylated hemoglobin, and morphologic changes in pancreas islet before and after treatment after 1 month.2. The second part of the research: Collected 50 patients with type 2 diabetes in strictly accordance with the inclusion criteria. All of them were treated with auricular vagus nerve stimulation for 30 minutes each day. Detected the changes of the fasting plasma glucose (FBG), blood glucose load after 2-hour 75g oral glucose tolerance test (P2BG),and glycosylated hemoglobin (HbAlc) of before and after treatment after 3 months.Results:1. The first part: there is no significant difference on the FBG and HbAlc between Group A and group B before and after treatment. FBG and HbAlc of the group C significantly decreased after treatment by stimulating the cavity of auricular concha of the diabetes rats .Isletβcells in the Group C decreased slightly compared with Group A, but increased when compared with Group B under the electron microscope.2. The second part: By Statistical analysis ,the HbAlc of 50 patients with type 2 diabetics significantly decreased(P<0.01)and FBG and P2BG of them decreased(P<0.05) slightly than before treatment after 3 months.Conclusion: We have reached an initial conclusion that auricular acupuncture can regulate blood sugar level and decrease FBG and HbAlc in the diabetes rats or patients with diabetes, at the same time, this treatment may prevent the complications of diabetes and repair damaged pancreaticβcells.