Immunological Characteristics Of Autoantibodies And The Clinical Application Value In Autoimmune Liver Disease Patients

Objective:Retrospective Analysis and Discussion on the characteristics of autoantibodies and its clinical significance In patients with autoimmune liver disease in Xinjiang. Methods:The 696 cases of subjects were divided into 3 groups. (1) AILD group:Including 41 patients of autoimmune hepatitis (AIH) and 142 patients of primary biliary cirrhosis (PBC); (2) Viral hepatitis group:184 cases of chronic hepatitis B,81 cases of chronic hepatitis B with cirrhosis,160 cases of chronic hepatitis C,32 cases of chronic hepatitis C with cirrhosis; (3) normal control group:56 patients. Autoantibody to Nuclear Antigen (ANA), antineutrophil cytoplasmic antibodies (ANCA), smooth muscleantibodies (SMA), and anti-mitochondrial antibody (AMA) are determined by immunofluorescence (IFF);anti-mitochondrial antibody-M2 (AMA-M2), anti-liver cytosol antigen typel (LC-1), liver/kidney microsomal antibody (LKM-1) C and anti-soluble liver antigen/liver-pancreas (SLA/LP) are determined by immunobiotting test (IBT). Result:Patients with autoimmune liver disease group (AILD group) ANA total positive rate was 88.5%, AIH Patients ANA positive rate was 65.9%, ASMA positive rate was 17%;PBC Patients ANA positive rate was 95.1%, AMA and AMA-M2 positive rate was 84.5%,82.4%, Viral hepatitis groups ANA total positive rate was 15. 1%, Normal control group ANA total positive rate was 12.5%, ANA positive for autoimmune liver disease group was higher than the other groups (P<0.01);ASMA positive test, AIH group was higher than the other groups (P<0.05);AMA positive test, PBC group was higher than the other groups (P<0.05). Conclusions:Each autoimmune liver diseases have their characteristic autoantibodies, It has important diagnosis and differential clinical significance of AILD to routinely detect autoantibodies by All types of chronic liver disease.